Frank J. Jenkins¹ and Sharon L. Turner²

¹ Department of Pathology, School of Medicine; 1Department of Infectious Diseases and Microbiology, School of Public Health;
^1,2 Division of Behavioral Medicine and Oncology, University of Pittsburgh Cancer Institute;
^1,2 Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213 USA

Received 08/02/96; Accepted 08/08/96; On-line 09/01/96

TABLE OF CONTENTS

1. Abstract

2. Introduction

2.1. HSV Infections

2.2. HSV Replicative Cycle

3. Demyelinating Disease

3.1. CNS vs PNS Infections

3.2. Role of Immunosuppression

4. Transneuronal Tracings

4.1. Properties of Effective Transneuronal Tracers

4.2. Viral-based Transneuronal Tracers

5. Gene Therapy

5.1. Neuronal Vectors

5.2. HSV-based vectors

6. Summary

7. References

8. Entire manuscript

Key Words: Herpes Simplex Virus, Neuroscience, Viral Vectors, Gene Therapy, Latency, Demyelination

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