[Frontiers in Bioscience 1, d103-117, July 1, 1996]
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CAVEAT LECTOR



MEMBRANE LIPID DYNAMICS DURING HUMAN SPERM CAPACITATION

Paz Martínez1 and Antoni Morros2

1 Instituto de Biología Fundamental. Unidad de Inmunología, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona) Spain.

2 Unitat de Biofísica. Departament de Bioquímica i de Biologia Molecular,Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona) Spain

Received 05/06/96; Accepted 06/18/96; On-line 07/01/96

TABLE OF CONTENTS
1. Abstract
2. Introduction
3. Lipid composition of mature sperm
4. Lipid changes during capacitation
4.1. Cholesterol efflux from sperm membrane
4.2. Cholesterol acceptors
5. Lipid domains and membrane fluidity
5.1. Macrodomains and microdomains
5.2. Biophysical, biochemical and cytochemical techniques for the analysis of lipid regionalization in the plasma membrane of sperm
5.3. Mechanisms accounting for the presence of distinct lipid domains
6. Role of fusogenic lipids in capacitation and acrosome reaction
7. A model for organization of lipids during capacitation
7.1. Cholesterol efflux
7.2. Effects of cholesterol efflux
8. Acknowledgments
9. References
10. Entire manuscript