[Frontiers in Bioscience 1, d177-188, August 1, 1996]
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CAVEAT LECTOR



NEW MECHANISMS OF REGULATION OF THE GENOMIC ACTIONS OF VITAMIN D IN BONE CELLS: INTERACTION OF THE VITAMIN D RECEPTOR WITH NON-CLASSICAL RESPONSE ELEMENTS AND WITH THE MULTIFUNCTIONAL PROTEIN, CALRETICULIN

René St-Arnaud1, G. Antonio Candeliere1, and Shoukat Dedhar2

1Genetics Unit, Shriners Hospital, and Departments of Surgery and Human Genetics, McGill University, Montréal (Québec) Canada H3G1A6

2Division of Cancer Research and Department of Medical Biophysics, University of Toronto, Reichmann Research Building, Sunnybrook Health Science Centre, Toronto (Ontario) Canada M4N 3M5

Received 07/05/96; Accepted 07/12/96; On-line 08/01/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. Vitamin D and bone cells
2.2. VDREs
2.3. VDR dimerization
3. Non-classical VDREs
3.1. In various promoters
3.2. In the promoter of the c-fos proto-oncogene
4. Protein-protein interactions of the VDR
4.1. With the basic transcriptional machinery
4.2. With NF-1
4.3. With calreticulin
5. Perspectives
6. Acknowledgments
7. References
8. Entire manuscript