[Frontiers in Bioscience 1, d270-308, October 1, 1996]
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PubMed
CAVEAT LECTOR



STRUCTURE-FUNCTION RELATIONSHIP IN THE IL-1 FAMILY

Diana Boraschi, Paola Bossù, Giovanni Macchia, Paolo Ruggiero & Aldo Tagliabue

Dept. Biotechnology, Research Center Dompé SpA, Via Campo di Pile, I-67100 L'Aquila Italy

Received 8/5/96; Accepted 9/11/96; On-line 11/01/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1 IL-1alpha, IL-1ß and IL-1ra
2.2 ICE
2.3 IL-1RI, IL-1RAcP and signal transduction
2.4 IL-1RII
2.5 Biological and pathological role
3. Discussion
3.1 Mutagenesis
3.2 Structural analysis
3.3 Models of ligand/receptor interaction
3.4 Perspective
4. References
5. Entire manuscript