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STRUCTURE-FUNCTION RELATIONSHIP IN THE IL-1 FAMILY
Diana Boraschi, Paola Bossù, Giovanni Macchia, Paolo
Ruggiero & Aldo Tagliabue
Dept. Biotechnology, Research Center Dompé SpA, Via
Campo di Pile, I-67100 L'Aquila Italy
Received 8/5/96; Accepted 9/11/96; On-line 11/01/96
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 2.1 IL-1alpha, IL-1ß and IL-1ra
- 2.2 ICE
- 2.3 IL-1RI, IL-1RAcP and signal transduction
- 2.4 IL-1RII
- 2.5 Biological and pathological role
- 3. Discussion
- 3.1 Mutagenesis
- 3.2 Structural analysis
- 3.3 Models of ligand/receptor interaction
- 3.4 Perspective
- 4. References
- 5. Entire manuscript
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