![]() ![]() | [Frontiers in Bioscience 1, d118-130, August 1, 1996] Reprints PubMed CAVEAT LECTOR |
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THE TAU PROTEINS IN NEURONAL GROWTH AND DEVELOPMENT
Institute of Neurobiology, University of Heidelberg, INF 364, 69120 Heidelberg, Germany. Received 05/21/96; Accepted 07/05/96; On-line 08/01/96
![]() 1. V. Meininger & S. Binet: Characteristics of microtubules at the different stages of neuronal differentiation and maturation. Int Rev Cytol 114, 21-79 (1989) 2. R. P. Tucker: The roles of microtubule-associated proteins in brain morphogenesis: a review. Brain Res Rev 15, 101-20 (1990) 3. M. Goedert, R. A. Crowther & C. C. Garner: Molecular characterization of microtubule-associated proteins tau and MAP2. Trends Neurosci 14, 193-9 (1991) 4. E. M. Mandelkow & E. Mandelkow: Tau as a marker for Alzheimer's disease. Trends Biochem Sci 18, 480-3 (1993) 5. K. S. Kosik: The Alzheimer's disease sphinx: a riddle with plaques and tangles. J Cell Biol 127, 1501-4 (1994) 6. M. D. Weingarten, A. H. Lockwood, S. Y. Hwo & M. W. Kirschner: A protein factor essential for microtubule assembly. Proc Natl Acad Sci USA 72, 1858-62 (1975) 7. D. W. Cleveland, S. Y. Hwo & M. W. Kirschner: Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol 116, 207-25 (1977) 8. G. B. Witman, D. W. Cleveland, M. D. Weingarten & M. W. Kirschner: Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci USA 73, 4070-4 (1976) 9. D. W. Cleveland, S. Y. Hwo & M. W. Kirschner: Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol 116, 227-47 (1977) 10. D. N. Drechsel, A. A. Hyman, M. H. Cobb & M. W. Kirschner: Modulation of the dynamic instability of tubulin assembly by the microtubule associated protein tau. Mol Biol Cell 3, 1141-54 (1992) 11. B. Trinczek, J. Biernat, K. Baumann, E. M. Mandelkow & E. Mandelkow: Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Mol Biol Cell 6, 1887-902 (1995) 12. L. M. Griffith & T. D. Pollard: Evidence for actin filament-microtubule interaction mediated by microtubule-associated proteins. J Cell Biol 78, 958-65 (1978) 13. L. M. Griffith & T. D. Pollard: The interaction of actin with microtubules and microtubule-associated proteins. J Biol Chem 257, 9143-51 (1982) 14. D. G. Drubin, S. C. Feinstein, E. M. Shooter & M. W. Kirschner: Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol 101, 1799-807 (1985) 15. D. Drubin, S. Kobayashi, D. Kellogg & M. Kirschner: Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells. J Cell Biol 106, 1583-91 (1988) 16. A. Ferreira, J. Busciglio & A. Caceres: Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau. Brain Res Dev Brain Res 49, 215-28 (1989) 17. B. Esmaeli-Azad, J. H. McCarty & S. C. Feinstein: Sense and antisense transfection analysis of tau function - tau influences net microtubule assembly, neurite outgrowth and neuritic stability. J Cell Sci 107, 869-79 (1994) 18. J. Francon, A. M. Lennon, A. Fellous, A. Mareck, M. Pierre & J. Nunez: Heterogeneity of microtubule-associated proteins and brain development. Eur J Biochem 129, (1982) 19. K. S. Kosik, L. D. Orecchio, S. Bakalis & R. L. Neve: Developmentally regulated expression of specific tau sequences. Neuron 2, 1389-97 (1989) 20. M. Goedert, M. G. Spillantini & R. A. Crowther: Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system. Proc Natl Acad Sci USA 89, 1983-7 (1992) 21. D. Couchie, C. Mavilia, I. S. Georgieff, R. K. Liem & J. Nunez: Primary structure of high molecular weight tau present in the peripheral nervous system. Proc Natl Acad Sci USA 89, 4378-81 (1992) 22. G. Lee: Tau protein: an update on structure and function. Cell Motil Cytoskel 15, 199-203 (1990) 23. G. Lee: Non-motor microtubule-associated proteins. Current Opinion in Cell Biol 5, 88-94 (1993) 24. G. Lee, R. L. Neve & K. S. Kosik: The microtubule binding domain of tau protein. Neuron 2, 1615-24 (1989) 25. K. A. Butner & M. W. Kirschner: Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol 115, 717-30 (1991) 26. B. L. Goode & S. C. Feinstein: Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau. J Cell Biol 124, 769-82 (1994) 27. N. Gustke, B. Trinczek, J. Biernat, E.-M. Mandelkow & E. Mandelkow: Domains of tau protein and interactions with microtubules. Biochemistry 33, 9511-22 (1994) 28. R. Brandt & G. Lee: Functional organization of microtubule-associated protein tau. Identification of regions which affect microtubule growth, nucleation, and bundle formation in vitro. J Biol Chem 268, 3414-9 (1993) 29. T. Hagestedt, B. Lichtenberg, H. Wille, E. M. Mandelkow & E. Mandelkow: Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation. J Cell Biol 109, 1643-51 (1989) 30. J. Biernat, N. Gustke, G. Drewes, E.-M. Mandelkow & E. Mandelkow: Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 11, 153-63 (1993) 31. G. Lindwall & R. D. Cole: Phosphorylation affects the ability of tau protein to promote microtubule assembly. J Biol Chem 259, 5301-5 (1984) 32. R. Brandt, G. Lee, D. B. Teplow, D. Shalloway & M. Abdel-Ghany: Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation. J Biol Chem 269, 11776-82 (1994) 33. D. G. Drubin & M. W. Kirschner: Tau protein function in living cells. J Cell Biol 103, 2739-46 (1986) 34. G. Lee & S. L. Rook: Expression of tau protein in non-neuronal cells: microtubule binding and stabilization. J Cell Sci 102, 227-37 (1992) 35. P. W. Baas, T. P. Pienkowski, K. A. Cimbalnik, K. Toyama, S. Bakalis, F. J. Ahmad & K. S. Kosik: Tau confers drug stability but not cold stability to microtubules in living cells. J Cell Sci 107, 135-43 (1994) 36. J. Knops, K. S. Kosik, G. Lee, J. D. Pardee, G. L. Cohen & L. McConlogue: Overexpression of tau in a nonneuronal cell induces long cellular processes. J Cell Biol 114, 725-33 (1991) 37. J. Léger, R. Brandt & G. Lee: Identification of tau protein regions required for process formation in PC12 cells. J Cell Sci 107, 3403-12 (1994) 38. K. Edson, B. Weisshaar & A. Matus: Actin depolymerisation induces process formation on MAP2-transfected non-neuronal cells. Development 117, 689-700 (1993) 39. A. Matus: Stiff microtubules and neuronal morphology. Trends Neurosci 17, 19-22 (1994) 40. S. C. Papasozomenos & L. I. Binder: Phosphorylation determines two distinct species of tau in the central nervous system. Cell Motil Cytoskel 8, 210-26 (1987) 41. A. Migheli, M. Butler, K. Brown & M. L. Shelanski: Light and electron microscope localization of the microtubule-associated tau protein in rat brain. J Neurosci 8, 1846-51 (1988) 42. L. I. Binder, A. Frankfurter & L. I. Rebhun: The distribution of tau in the mammalian central nervous system. J Cell Biol 101, 1371-8 (1985) 43. N. W. Kowall & K. S. Kosik: Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease. Ann Neurol 22, 639-43 (1987) 44. J. P. Brion, J. Guilleminot, D. Couchie, D. J. Flament & J. Nunez: Both adult and juvenile tau microtubule-associated proteins are axon specific in the developing and adult rat cerebellum. Neuroscience 25, 139-46 (1988) 45. J. Q. Trojanowski, T. Schuck, M. L. Schmidt & V. M. Lee: Distribution of tau proteins in the normal human central and peripheral nervous system. J Histochem Cytochem 37, 209-15 (1989) 46. R. Bernhardt & A. Matus: Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons. J Comp Neurol 226, 203-21 (1984) 47. P. DeCamilli, P. E. Miller, F. Navone, W. E. Theurkauf & R. B. Vallee: Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence. Neuroscience 11, 817-46 (1984) 48. C. Viereck, R. P. Tucker, L. I. Binder & A. Matus: Phylogenetic conservation of brain microtubule-associated proteins MAP2 and tau. Neuroscience 26, 893-904 (1990) 49. P. R. Burton & J. L. Paige: Polarity of axoplasmic microtubules in the olfactory nerve of the frog. Proc Natl Acad Sci USA 78, 3269-73 (1981) 50. S. R. Heidemann, J. M. Landers & M. A. Hamborg: Polarity orientation of axonal microtubules. J Cell Biol 91, 661-5 (1981) 51. P. W. Baas, J. S. Deitch, M. M. Black & G. A. Banker: Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc Natl Acad Sci USA 85, 8335-9 (1988) 52. I. Nadelhaft: Microtubule densities and total numbers in selected axons of the crayfish abdominal nerve cord. J Neurocytol 3, 73-86 (1974) 53. J. Chen, Y. Kanai, N. J. Cowan & N. Hirokawa: Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature 360, 674-7 (1992) 54. P. W. Baas, T. P. Pienkowski & K. S. Kosik: Processes induced by tau expression in Sf9 cells have an axon-like microtubule organization. J Cell Biol 115, 1333-44 (1991) 55. P. W. Baas, M. M. Black & G. A. Banker: Changes in microtubule polarity orientation during the development of hippocampal neurons in culture. J Cell Biol 109, 3085-94 (1989) 56. I. Peng, L. I. Binder & M. M. Black: Biochemical and immunological analyses of cytoskeletal domains of neurons. J Cell Biol 102, 252-62 (1986) 57. C. G. Dotti, G. A. Banker & L. I. Binder: The expression and distribution of the microtubule-associated proteins tau and microtubule-associated protein 2 in hippocampal neurons in the rat in situ and in cell culture. Neuroscience 23, 121-30 (1987) 58. K. S. Kosik & E. A. Finch: MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum. J Neurosci 7, 3142-53 (1987) 59. P. Litman, J. Barg, L. Rindzoonski & I. Ginzburg: Subcellular localization of tau mRNA in differentiating neuronal cell culture: implications for neuronal polarity. Neuron 10, 627-38 (1993) 60. P. W. Baas, G. I. Sinclair & S. R. Heidemann: Role of microtubules in the cytoplasmic compartmentation of neurons. Brain Res 420, 73-81 (1987) 61. M. Mercken, I. Fischer, K. S. Kosik & R. A. Nixon: Three distinct axonal transport rates for tau, tubulin, and other microtubule associated proteins: evidence for dynamic interactions of tau with microtubules in vivo. J Neurosci 15, 8259-67 (1995) 62. S. Okabe & N. Hirokawa: Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons. Proc Natl Acad Sci USA 86, 4127-31 (1989) 63. N. Hirokawa, T. Funakoshi, R. Satoharada & Y. Kanai: Selective stabilization of tau in axons and microtubule associated protein 2c in cell bodies and dendrites contributes to polarized localization of cytoskeletal proteins in mature neurons. J Cell Biol 132, 667-79 (1996) 64. M. Mercken, F. Grynspan & R. A. Nixon: Differential sensitivity proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau. FEBS Lett 368, 10-4 (1995) 65. J. M. Litersky & G. V. Johnson: Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain. J Biol Chem 267, 1563-8 (1992) 66. J. M. Litersky & G. V. Johnson: Phosphorylation of tau in situ: inhibition of calcium-dependent proteolysis. J Neurochem 65, 903-11 (1995) 67. A. Ferreira, R. Kincaid & K. S. Kosik: Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity. Mol Biol Cell 4, 1225-38 (1993) 68. Y. Kanai & N. Hirokawa: Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding. Neuron 14, 421-32 (1995) 69. N. Gustke, B. Steiner, E. M. Mandelkow, J. Biernat, H. E. Meyer, M. Goedert & E. Mandelkow: The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs. FEBS Lett 307, 199-205 (1992) 70. M. DiTella, F. Feiguin, G. Morfini & A. Cáceres: Microfilament-associated growth cone component depends upon tau for its intracellular localization. Cell Motil Cytoskel 29, 117-30 (1994) 71. R. Brandt, J. Léger & G. Lee: Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J Cell Biol 131, 1327-40 (1995) 72. C. G. Dotti, C. A. Sullivan & G. A. Banker: The establishment of polarity by hippocampal neurons in culture. J Neurosci 8, 1454-68 (1988) 73. A. Cáceres & K. S. Kosik: Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons. Nature 343, 461-3 (1990) 74. A. Cáceres, S. Potrebic & K. S. Kosik: The effect of tau antisence oligonucleotides on neurite formation of cultured cerebellar macroneurons. J Neuroscience 11, 1515-23 (1991) 75. A. Cáceres, J. Mautino & K. S. Kosik: Suppression of MAP-2 in cultured cerebellar macroneurons inhibits minor neurite formation. Neuron 9, 607-18 (1992) 76. A. Harada, K. Oguchi, S. Okabe, J. Kuno, S. Terada, T. Ohshima, R. Sato-Yoshitake, Y. Takei, T. Noda & N. Hirokawa: Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369, 488-91 (1994) 77. J. Götz, A. Probst, M. G. Spillantini, T. Schäfer, R. Jakes, K. Bürki & M. Goedert: Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J 14, 1304-13 (1995) 78. H. Zheng, M. Jiang, M. E. Trumbauer, D. J. S. Sirinathsinghji, R. Hopkins, D. W. Smith, R. P. Heavens, G. R. Dawson, S. Boyce, M. W. Conner, K. A. Stevens, H. H. Slunt, S. S. Sisodia, H. Y. Chen, L. H. T. Van der Ploeg: Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomoter activity. Cell 81, 525-31 (1995) 79. J. Eyer & A. Peterson: Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galctosidase fusion protein. Neuron 12, 389-405 (1994) 80. D. A. Steindler, D. Settles, H. P. Erickson, E. D. Laywell, A. Yoshiki, A. Faissner & M. Kusakabe: Tenascin knockout mice: barrels, boundary molecules, and glial scars. J Neurosci 15, 1971-83 (1995) 81. M. Kempf, A. Clement, A. Faissner, G. Lee & R. Brandt: Tau binds to the distal axon early in development of polarity in a microtubule- and microfilament-dependent manner. J Neurosci, in press 82. M. Black, T. Slaughter, S. Moshiach, M. Obrocka & I. Fischer: Tau is enriched on dynamic microtubules in the distal region of growing axons. J Neurosci, in press 83. J. R. Bamburg, D. Bray & K. Chapman: Assembly of microtubules at the tip of growing axons. Nature 321, 788-90 (1986) 84. M. Goedert & R. Jakes: Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization. EMBO J 9, 4225-30 (1990) 85. N. Hirokawa, Y. Shiomura & S. Okabe: Tau proteins: the molecular structure and mode of binding on microtubules. J Cell Biol 107, 1449-59 (1988) 86. N. Leclerc, P. W. Baas, C. C. Garner & K. S. Kosik: Juvenile and mature MAP2 isoforms induce distinct patterns of process outgrowth. Mol Biol Cell 7, 443-55 (1996) 87. H. M. Rubino, M. Dammermann, B. Shaft-Zagardo & J. Erlichman: Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2. Neuron 3, 631-8 (1989) 88. R. A. Obar, J. Dingus, H. Bayley & R. B. Vallee: The RII subunit of cAMP-dependent protein kinase binds to a common amino-terminal domain in microtubule-associated proteins 2A, 2B, and 2C. Neuron 3, 639-45 (1989) 89. I. Correas, R. Padilla & J. Avila: The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding. Biochem J 269, 61-4 (1990) 90. N. Hirokawa. Molecular architecture and dynamics of the neuronal cytoskeleton. In: The neuronal cytoskeleton. Ed: R. D. Burgoyne. Wiley-Liss: New York, 5-74 (1991) 91. G. Lee & R. Brandt: Microtubule bundling studies revisited: is there a role for MAPs? Trends Cell Biol 2, 286-9 (1992) 92. Y. Kanai, J. Chen & N. Hirokawa: Microtubule bundling by tau protein in vivo: analysis by functional domains. EMBO J 11, 3953-61 (1992) 93. D. J. Ennulat, R. K. Liem, G. A. Hashim & M. L. Shelanski: Two separate 18-amino acid domains of tau promote the polymerization of tubulin. J Biol Chem 264, 5327-30 (1989) 94. R. Melki, P. Kerjan, J. P. Waller, M. F. Carlier & D. Pantaloni: Interaction of microtubule-associated proteins with microtubules: yeast lysyl- and valyl-tRNA synthetases and tau 218-235 synthetic peptide as model systems. Biochemistry 30, 11536-45 (1991) 95. R. Brandt & G. Lee: Orientation, assembly, and stability of microtubule bundles induced by a fragment of tau protein. Cell Motil Cytoskel 28, 143-54 (1994) 96. M. F. Carlier, C. Simon, R. Cassoly & L. A. Pradel: Interaction between microtubule-associated protein tau and spectrin. Biochimie 66, 305-11 (1984) 97. J. Kirsch, D. Langosch, P. Prior, U. Z. Littauer, B. Schmitt & H. Betz: The 93-kDa glycine receptor-associated protein binds to tubulin. J Biol Chem 266, 22242-5 (1991) 98. J. Kirsch & H. Betz: The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J Neurosci 15, 4148-56 (1995) 99. A. M. Craig, R. J. Wyborski & G. Banker: Preferential addition of newly synthesized membrane protein at axonal growth cones. Nature 375, 592-4 (1995) 100. J. Dai & M. P. Sheetz: Axon membrane flows from the growth cone to the cell body. Cell 83, 693-701 (1995) 101. B. Winckler & M. Poo: No diffusion barrier at axon hillock. Nature 379, 213 (1996) 102. K. Ishiguro, A. Omori, M. Takamatsu, K. Sato, M. Arioka, T. Uchida & K. Imahori: Phosphorylation sites on tau by tau protein kinase I, a bovine derived kinase generating an epitope of paired helical filaments. Neurosci Lett 148, 202-6 (1992) 103. K. Ishiguro, A. Shiratsuchi, S. Sato, A. Omori, M. Arioka, S. Kobayashi, T. Uchida & K. Imahori: Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett 325, 167-72 (1993) 104. S. D. Yang, J. S. Song, J. S. Yu & S. G. Shiah: Protein kinase FA/GSK-3 phosphorylates tau on Ser235-Pro and Ser404-Pro that are abnormally phosphorylated in Alzheimer's disease brain. J Neurochem 61, 1742-7 (1993) 105. S. D. Yang, J. S. Yu, S. G. Shiah & J. J. Huang: Protein kinase FA/glycogen synthase kinase-3 alpha after heparin potentiation phosphorylates tau on sites abnormally phosphorylated in Alzheimer's disease brain. J Neurochem 63, 1416-25 (1994) 106. R. Vulliet, M. Halloran, A. Smith & G. Lee: Proline-directed phosphorylation of human tau protein. J Biol Chem 267, 22570-4 (1992) 107. C. W. Scott, R. C. Spreen, J. L. Herman, F. P. Chow, M. D. Davison, J. Young & C. B. Caputo: Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly. J Biol Chem 268, 1166-73 (1993) 108. I. Correas, N. Diaz, J. & J. Avila: Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain. J Biol Chem 267, 15721-8 (1992) 109. B. Steiner, E. M. Mandelkow, J. Biernat, N. Gustke, H. E. Meyer, B. Schmidt, G. Mieskes, H. D. Soling, D. Drechsel, M. W. Kirschner, M. Goedert, E. Mandelkow: Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2+-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J 9, 3539-44 (1990) 110. A. Andreadis, W. M. Brown & K. S. Kosik: Structure and novel exons of the human tau gene. Biochemistry 31, 10626-33 (1992) 111. A. Watanabe, M. Hasegawa, M. Suzuki, K. Takio, M. Morishima-Kawashima, K. Titani, T. Arai, K. S. Kosik & Y. Ihara: In vivo phosphorylation sites in fetal and adult rat tau. 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