[Frontiers in Bioscience 1, d324-339, November 1, 1996]
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CAVEAT LECTOR



INVASION OF HUMAN GLIOMA: ROLE OF EXTRACELLULAR MATRIX PROTEINS

Shravan K. Chintala, Ph.D. and Jasti S. Rao, Ph.D.

Department of Neurosurgery, Box 064, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Received 9/28/96; Accepted 10/17/96; On-line 11/01/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Extracellular matrix components
3.1. Proteoglycans
3.2. Myelin
3.3. Fibronectin
3.4. Vitronectin
3.5. Tenascins
3.6. Laminins
3.7. Type IV collagen
4. Gliomas
4.1. Invasion
5. ECM receptors and cell adhesion molecules
5.1. Gangliosides
5.2. Cluster differentiation 44
5.3. Neural cell adhesion molecule
5.4. Integrins
6. ECM turnover and degradation
6.1. Matrix metalloproteases
6.2. Plasminogen activators
7. Perspectives
8. Acknowledgments
9. References
10. Entire manuscript
Key Words: Glioma, invasion, extracellular matrix, proteolytic enzymes