[Frontiers in Bioscience 1, d161-176, August 1, 1996]
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ADHESION MOLECULES IN HUMAN SPERM-OOCYTE INTERACTION: RELEVANCE TO INFERTILITY

Osmond J. D'Cruz, Ph.D

Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Sperm-oocyte fusion
4. Assessment of sperm-oocyte interaction
4.1. Human sperm-zona-free hamster oocyte penetration assay
4.2. Human sperm-zona-free human oocyte fusion test
4.3. The subzonal sperm insertion technique
4.4. Intracytoplasmic sperm injection
4.5. Hybridoma/molecular cloning approach
5. Molecules implicated in sperm-oocyte interaction
5.1. Adhesion molecules on the sperm
5.1.1. Fertilins
5.1.2. ß1 integrins
5.1.3. ß2 integrins
5.1.4. Complement inhibitors
5.1.5. Calmodulin
5.2. Adhesion molecules on the oolemma
6. Sperm-oocyte fusion and transmission of HIV
7. Factors impairing sperm-oocyte fusion
7.1. Free radical-mediated lipid peroxidation
7.2. Immature sperm surface proteins
7.3. Abnormal nuclear condensation
7.4. Antisperm antibodies
8. Concluding remarks
9. References
10. Entire manuscript

Key words: Adhesion molecules, integrins, infertility, oocyte, sperm