[Frontiers in Bioscience 1, d234-240, September 1, 1996]


Christopher De Jonge, Ph.D., HCLD

Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska, USA

Received 05/30/96; Accepted 07/14/96; On-line 09/01/96


1. M. C. Chang: Fertilizing capacity of spermatozoa deposited in fallopian tubes. Nature 168, 997-998 (1951)

2. C. R. Austin: The "capacitation" of the mammalian sperm. Nature 170, 326 (1952)

3. C. R. Austin: Sperm maturation in the male and female genital tracts. In: Eds: Metz C B, Monroy A, Biology of Fertilization 2, New York: Academic Press, 121-155 (1985)

4. J. M. Bedford: Sperm capacitation and fertilization in mammals. Biol Reprod 2(suppl), 128-158 (1970)

5. J. M. Bedford, G. W. Cooper: Membrane fusion events in fertilization of vertebrate eggs. Eds: Poste G, Nicolson GL, Membrane Surface Reviews (Membrane Fusion) 5, Amsterdam: North-Holland, 65-125 (1978).

6. J. M. Bedford, D. D. Hoskins: The mammalian spermatozoa: morphology, biochemistry and physiology. Ed: Lamming GE, Physiology of Reproduction 2, Edinburgh: Churchill Livingston, 379-658 (1990)

7. M. C. Chang: Meaning of sperm capacitation. J Androl 5, 45-50 (1984)

8. E. D. Clegg: Mechanisms of mammalian sperm capacitation. Ed: Hartman JF, Mechanism and Control of Animal Fertilization. New York: Academic Press, 177-212 (1983).

9. B. K. Davis, R. Byrne, K. Bedigan: Studies on the mechanism of capacitation: albumin mediated changes in plasma membrane lipids during in vitro incubation of rat cells. Proc Natl Acad Sci USA 77, 387-397 (1980)

10. E. Drobnis: Capacitation and acrosome reaction. Eds: Scialli AR, Zinaman MJ, Reproductive Toxicology and Infertility. New York: McGraw- Hill, 77-132 (1993)

11. H. M. Florman, D. F. Babcock: Progress toward understanding the molecular basis of capacitation. Ed: Wassarman PM, Elements of Mammalian Fertilization 1, Boca Raton, Florida: CRC Press, 105-132 (1991).

12. L. R. Fraser: Requirements for successful mammalian sperm capacitation and fertilization. Arch Path Lab Med 116, 345-350 (1992)

13. A. C. Hinrichsen-Kohane, M. J. Hinrichsen , W. B. Schill: Molecular events leading to fertilization. Andrologia 16, 321-341 (1984)

14. J. Langlais, K. D. Roberts: A molecular membrane model of sperm capacitation and the acrosome reaction of mammalian spermatozoa. Gamete Res 12, 183-224 (1985)

15. M. G. O'Rand: Changes in sperm surface properties correlated with capacitation. Eds: Fawcett DW, Bedford JM, The Spermatozoa. Baltimore: Urban and Schwarzenberg, 195-204 (1979)

16. M. G. O'Rand: Modification of the sperm membrane during capacitation. Ann NY Acad Sci 383, 392-404 (1982)

17. B. J. Rogers: Mammalian sperm capacitation and fertilization in vitro: a critique of methodology.Gamete Res 1, 165-223 (1978)

18. B. J. Rogers, B. J. Bentwood: Capacitation, acrosome reaction and fertilization. Eds: Zaneveld LJD, Chatterton RT, Biochemistry of Mammalian Fertilization. New York: Wiley, 203-230 (1982)

19. K. S. Sidhu, S. S. Guraya. Cellular and molecular biology of capacitation and acrosome reaction in mammalian spermatozoa. Int Rev Cytol 118, 231- 280 (1989)

20. B. T. Storey: Sperm capacitation and the acrosome reaction. Ann NY Acad Sci 637, 457-473 (1991)

21. R. Yanagimachi: Mammalian fertilization. Eds: Knobil E, Neill J, The Physiology of Reproduction 1, New York: Raven Press 189-317 (1994)

22. L. J. D. Zaneveld, C. J. De Jonge, R.A. Anderson, S. R. Mack: Human sperm capacitation and the acrosome reaction. Human Reprod 6, 1265-74 (1991)

23. K. J. Go, D. P. Wolf: Albumin mediated changes in sperm sterol content during capacitation. Biol Reprod 32,145-53 (1985)

24. R. A. Anderson Jr., K. A. Feathergill, C. J. De Jonge, S. R. Mack, L. J. D. Zaneveld: Facilitative effect of pulsed addition of dibutyryl cAMP on the acrosome reaction of noncapacitated spermatozoa. J Androl 13, 398- 408 (1992)

25. R. A. Anderson, K. A. Feathergill, R. C. Drisdel, R. G. Rawlins, S. R. Mack, L. J. D. Zaneveld: Atrial natriuretic peptide (ANP) as a stimulus of the human acrosome reaction and a component of ovarian follicular fluid: correlation of follicular ANP content with in vitro fertilization outcome. J Androl 15, 61-70 (1994)

26. L. J. D. Zaneveld, R. A. Anderson, S. R. Mack, C. J. De Jonge: Mechanism and control of the human sperm acrosome reaction. Human Reprod 8, 2006-8 (1994)

27. A Comparative Overview of Mammalian Fertilization. Eds: Dunbar BS, O'Rand MG, New York: Plenum Press (1991)

28. G. S. Kopf, G. L. Gerton: The mammalian sperm acrosome and the acrosome reaction. Ed: Wassarman PM, Elements of Mammalian Fertilization 1. Boca Raton, Florida: CRC Press, 153-203 (1991)

29. S. Meizel: The mammalian sperm acrosome reaction. A biochemical approach. Ed: Johnson MH, Development in Mammals. New York: North Holland, 1-64 (1978)

30. S. Meizel: Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am J Anat 174, 285-302 (1985)

31. L. J. D. Zaneveld, C. J. De Jonge: Mammalian sperm acrosomal enzymes and the acrosome reaction. Eds: Dunbar BS, O'Rand MG, A Comparative Overview of Mammalian Fertilization. New York: Plenum Press, 63-79 (1991)

32. C. J. De Jonge, C. L. R. Barratt, E. Radwanska, I. D. Cooke: The acrosome reaction inducing effect of human follicular and oviductal fluid. J Androl 14, 359-65 (1993)

33. J. Tesarik: Comparison of acrosome reaction-inducing activities of human cumulus oophorus, follicular fluid and ionophore A23187 in human sperm populations of proven fertilizing ability in vitro. J Reprod Fertil 74, 383-8 (1985)

34. S. Meizel, M. C. Pillai, E. Diaz-Perez, P. Thomas: Initiation of the human sperm acrosome reaction by components of human follicular fluid and cumulus secretions including steroids. Eds: Bavister BD, Cummins J, Roldan ERS, Fertilization in Mammals. Norwell, Massachusetts: Serono Symposia, USA, 205-22 (1991)

35. S. S. Suarez, D. P. Wolf, S. Meizel: Induction of the acrosome reaction in human spermatozoa by a fraction of human follicular fluid. Gamete Res 14, 107-21 (1986)

36. C. J. De Jonge, H-L Han, S. R. Mack, L. J. D. Zaneveld: Effect of phorbol diesters, synthetic diacylglycerols, and a protein kinase inhibitor on the human sperm acrosome reaction. J Androl 12, 62-70 (1991)

37. C. J. De Jonge, H-L Han, H. Lawrie, S. R. Mack,L. J. D. Zaneveld: Modulation of the human sperm acrosome reaction by effectors of the adenylate cyclase/cyclic AMP second messenger pathway. J Exp Zool 258, 113-25 (1991)

38. C. J. De Jonge, S. R. Mack, E. Radwanska, L. J. D. Zaneveld: Regulation of the human sperm acrosome reaction by two second messenger pathways. In: Baccetti B ed. Comparative Spermatology 20 Years After 75, New York: Serono Symposia Publications, Raven Press, 43-7 (1991)

39. L. Birnbaumer: Transduction of receptor signal into modulation of effector activity by G proteins: the first 20 years or so. FASEB J 4, 3068-78 (1990)

40. L. Birnbaumer, J. Abramowitz, A. M. Brown: Receptor-effector coupling by G proteins. Biochim Biophys Acta 1031, 163-224 (1990)

41. M. J. Berridge: The molecular basis of communication in the cell. Sci Am 253, 142-52 (1985)

42. C. J. De Jonge, S. R. Mack, L. J. D. Zaneveld: Inhibition of the human sperm acrosome reaction by proteinase inhibitors. Gamete Res 23, 387- 397 (1989)

43. N. B. Garty, D. Galiani, A. Aharonheim, Y-K Ho, D. M. Phillips, N. Dekel, Y. Salomon: G-proteins in mammalian gametes: an immunocytochemical study. J Cell Sci 99, 21-31 (1988)

44. P. Thomas, S. Meizel: Phosphatidylinositol 4,5-biphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx. Biochem J 264, 539-46 (1989)

45. E. R. S. Roldan, R. A. P. Harrison: Polyphosphoinositide breakdown and subsequent exocytosis in the Ca2+/ionophore-induced acrosome reaction of mammalian spermatozoa. Biochem J 259, 397-406 (1989)

46. P. Bielfeld, A. Faridi, L. J. D. Zaneveld, C. J. De Jonge: The zona pellucida-induced acrosome reaction of human spermatozoa is mediated by protein kinases. Fertil Steril 61, 536-41 (1994)

47. J. Tesarik, C. Mendoza , J. Moos, A. Carreras: Selective expression of a progesterone receptor on the human sperm surface. Fertil Steril 58, 84-92 (1992)

48. C. Doherty, S. M. Tarchala, E. Radwanska, C. J. De Jonge: Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction. J Androl 16, 36-46 (1995)

49. P. Thomas, S. Meizel: An influx of extracellular calcium is required for initiation of the human sperm acrosome reaction induced by human follicular fluid. Gamete Res 20, 397-411 (1988)

50. P. F. Blackmore, S. J. Beebe, D. R. Danforth, N. Alexander: Progesterone and 17alpha-hydroxy-progesterone novel stimulators of calcium influx in human sperm. J Biol Chem 265, 1376-80 (1990)

51. E. Baldi, R. Casano, C. Flasetti, C. Krausz, M. Maggi, G. Forti: Intracellular calcium accumulation and responsiveness to progesterone in capacitating human spermatozoa. J Androl 12, 323-30 (1991)

52. J. Parinaud, B. Labal, G. Vieitez: High progesterone concentrations induce acrosome reaction with a low cytotoxic effect. Fertil Steril 58, 599-602 (1992)

53. C. A. Wistrom, S. Meizel: Evidence suggesting involvement of a unique human sperm steroid receptor/Cl- channel complex in the progesterone-initiated acrosome reaction. Develop Biol 159, 679-90 (1993)

54. C. J. De Jonge, S. R. Mack, L. J. D. Zaneveld: Synchronous assay for human sperm capacitation and the acrosome reaction. J Androl 10, 232-9 (1989)

55. L. J. D. Zaneveld, R. S. Jeyendran: Modern assessment of semen for diagnostic purposes. Sem Reprod Endocrinol 6,323-37 (1988)

56. S. R. Mack, C. J. De Jonge, P. Bielfeld, L. J. D. Zaneveld: Acrosome reaction of human spermatozoa: Comparative evaluation by triple stain and electron microscopy. Mol Androl 2, 265-79 (1990)

57. M. J. Berridge, R. F. Irvine: Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315-21 (1984)

58. B. D. Gomperts: Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors. Nature 306, 64-6 (1983)

59. K. B. Seamon, J. W. Daly: Forskolin: Its biological and chemical properties. Eds: Greengard P, Robison GA, Advances in Cyclic Nucleotide and Protein Phosphorylation Research New York: Raven Press, 1-125 (1986)

60. C. Londos, J. Wolff, D. M. F. Cooper: Adenosine as a regulator of adenylate cyclase. In: G. Burnstock, ed. Purinergic Receptors New York: Chapman and Hall, 287-323 (1981)

61. H. Kase, K. Iwahashi, S. Nakanishi, Y. Matsuda, K. Yamada, M. Takahashi , C. Murakata, A. Sato, M. Kaneko. Biochem Biophys Res Comm 142, 436- 440 (1987)

62. E. Kobayashi, K. Ando, H. Nakano, T. Iida, H. Ohno, M. Morimoto, T. Tamaoki: Calphostins (UCN-1028, novel and specific inhibitor of protein kinase C. I: fermentation, isolation, physicochemical properties and biological activities. J Antibiot (Tokyo) 42, 1470-4 (1989)

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