[Frontiers in Bioscience 1, d234-240, September 1, 1996]
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CAVEAT LECTOR



THE cAMP-DEPENDENT KINASE PATHWAY AND HUMAN SPERM ACROSOMAL EXOCYTOSIS

Christopher De Jonge, Ph.D., HCLD

Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska, USA

Received 05/30/96; Accepted 07/14/96; On-line 09/01/96

TABLE OF CONTENTS

1. Abstract
2. Background
2.1. Capacitation
2.2. Acrosome reaction
2.3. Communication between sperm and egg
2.4. Model for intracellular signal-induced acrosomal exocytosis
3. Experimental evidence for PKA involvement in the acrosome reaction
3.1. Assay conditions
3.2. cAMP and calcium
3.3. Adenylate cyclase
3.4. cAMP-dependent kinase
3.5. Solubilized zona pellucida
3.6. Human follicular fluid
4. Conclusions
5. References
6. Entire manuscript

Key words: Fertilization, human spermatozoa, signal transduction, exocytosis, cAMP-dependent kinase.