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THE cAMP-DEPENDENT KINASE PATHWAY AND HUMAN SPERM ACROSOMAL
EXOCYTOSIS
Christopher De Jonge, Ph.D., HCLD
Department of Obstetrics and Gynecology, University of Nebraska
Medical Center, Omaha, Nebraska, USA
Received 05/30/96; Accepted 07/14/96; On-line 09/01/96
TABLE OF CONTENTS
- 1. Abstract
- 2. Background
- 2.1. Capacitation
- 2.2. Acrosome reaction
- 2.3. Communication between sperm and egg
- 2.4. Model for intracellular signal-induced acrosomal exocytosis
- 3. Experimental evidence for PKA involvement in the acrosome
reaction
- 3.1. Assay conditions
- 3.2. cAMP and calcium
- 3.3. Adenylate cyclase
- 3.4. cAMP-dependent kinase
- 3.5. Solubilized zona pellucida
- 3.6. Human follicular fluid
- 4. Conclusions
- 5. References
- 6. Entire manuscript
Key words: Fertilization, human spermatozoa, signal transduction,
exocytosis, cAMP-dependent kinase.
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