[Frontiers in Bioscience 1, d91-116, July 1, 1996]
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CAVEAT LECTOR



THE PATTERN AND MECHANISM OF MITOCHONDRIAL TRANSPORT IN AXONS

Peter J. Hollenbeck

Dept. of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

Received 05/30/96; Accepted 06/10/96; On-line 07/01/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. What is the nature of mitochondrial movement in nerve axons?
3.2. What are the possible motors and tracks?
3.2.1 Molecular motors for mitochondrial transport
3.2.2 Two different cytoskeletal tracks for mitochondrial movement
3.3. How is movement regulated to support neuronal homeostasis?
3.3.1 The coordination of mitochondrial motility behavior with axonal physiology
3.3.2 Potential signals for controlling mitochondrial motility
3.4. What is the nature of mitochondrial "docking?"
3.5 Summary
4. Acknowledgments
5. References
6. Entire manuscript