[Frontiers in Bioscience 1, d59-71, March 1, 1996]
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CAVEAT LECTOR



THE ANDROGEN RECEPTOR: A MEDIATOR OF DIVERSE RESPONSES

Evan T. Keller, William B. Ershler, and Chawnshang Chang

The Institute on Aging and the Department of Human Oncology, University of Wisconsin, Madison, WI 53706, USA.

Received 01/16/96; Accepted 02/22/96; On-line 03/01/96

TABLE OF CONTENTS
1. Abstract
2. Introduction
3. An overview of the androgen receptor
3.1 Androgen Receptor Structure
3.2 Distribution of the Androgen Receptor
3.3 Regulation of Androgen Receptor Expression
3.4 The Androgen Receptor Gene 5'-flanking Region
4. How do androgens achieve distinct effects on various epithelial populations?
5. Why are there two androgens (testosterone and dihydrotestosterone) active on one androgen receptor?
6. Why are both consensus and non-consensus androgen response elements present ?
7. How does a nonspecific steroid response element confer androgen specific action?
8. How does prostate cancer acquire androgen independence?
9. Summary
10. Acknowledgments
11. References
12. Entire manuscript