![]() ![]() | [Frontiers in Bioscience 1, d340-357, December 1, 1996] Reprints PubMed CAVEAT LECTOR |
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MOLECULAR AND CELLULAR BIOLOGY OF INTERLEUKIN-6 AND ITS RECEPTOR Evan T. Keller1,2,3, Jon Wanagat1, W.B. Ershler1,3 1Glennan Center for Geriatrics and Gerontology, Departments of 2Pathology and 3Internal Medicine, Eastern Virginia Medical School.
Received 10/21/96; Accepted 11/01/96; On-line //96
![]() 1. S. Akira, T. Taga & T. Kishimoto: Interleukin-6 in biology and medicine. Adv Immunol 54, 1-78 (1993) 2. J. Weissenbach, Y. Chernajovsky, M. Zeevi, L. Shulman, H. Sorecq, U. Nir, D. Wallach, M. Perricaude, P. Tiollais & M. Revel: Two interferon mRNA in human fibroblasts: In vitro translation and Escheria coli cloning studies. Proc Natl Acad Sci USA 77, 7152-7156 (1980) 3. P. B. Sehgal, G. Greininger & G. Tosato: Acute Phase and Immune Responses: Interleukin-6. Ann NY Acad Sci 557, 1-583 (1989) 4. T. Hirano, T. Teranishi, B. H. Lin & K. Onoue: Human helper T cell factor(s). IV. Demonstration of a human late-acting B cell differentiation factor actin on Staphylococcus aureus Cowen I-stimulated B cells. J Immunol 133, 798-802 (1984) 5. A. Muraguchi, T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakamima & T. Kishimoto: The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J Exp Med 67, 332-344 (1988) 6. T. Taga, Y. Kawanishi, T. T. Hardy, T. Hirano & T. Kishimoto: Receptors for B cell stimulatory factor 2. J Exp Med 166, 967-981 (1987) 7. D. M. Ambrosino, N. R. Delaney & R. C. Shamberger: Human polysaccharide-specific B cells are responsive to pokeweed mitogen and IL-6. J Immunol 144, 1221-1226 (1990) 8. F. Takatsuki, A. Okano, C. Suzuki, R. Chieda, Y. Takahara, T. Hirano, T. Kishimoto, J. Hamuro & Y. Akiyama: Human recombinant IL-6/B cell-stimulatory factor 2 augments murine antigen-specific antibody responses in vitro and in vivo. J Immunol 141, 3072-3077 (1988) 9. C. Uyttenhove, P. G. Coulie & J. Van Snick: T cell growth and differentiation induced by interleukin HP1/IL-6, the murine hybridoma/plasmacytoma growth factor. J Exp Med 167, 1414-1427 (1988) 10. M. Lotz, F. Jirik, R. Kabouridis, C. Tsoukas, T. Hirano, T. Kishimoto & D. Carson: B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med 167, 1253-1258 (1988) 11. M. Helle, J. P. J. Brakenhoff, E. T. DeGroot & L. A. Aarden: Interleukin-6 is involved in interleukin-1-induced activities. Eur J Immunol 18, 957-959 (1988) 12. M. Okada, N. Kitahara, S. Kishimoto, T. Matsuda, T. Hirano & T. Kishimoto: IL-6/BSF-2 functions as a killer helper factor in the in vitro induction of cytotoxic T cells. J Immunol 141, 1543-1549 (1988) 13. J. C. Renauld, A. Vink & J. Van Snick: IL1 and IL6 in CTL induction-accessory signals in murine cytolytic T cell responses: Dual requirement for IL1 and IL6. J Immunol 143, 1894-1898 (1989) 14. T. A. Luger, J. Krutman, T. Kirnbauer, A. Urbanski, T. Schwarz, G. Klappacher, A. Kock, M. Micksche, K. J. Malejczy, E. Schauer, L. T. May, & P. B. Sehgal: IFNß/IL-6 augments the activity of human natural killer cells. J Immunol 143, 1206-1209 (1989) 15. N. Kurihara, D. Bertolini, T. Suda, Y. Akiyama & G. D. Roodman: IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 144, 4226-4230 (1990) 16. T. Tamura, N. Udagawa, N. Takahashi, C. Miyaura, S. Tanaka, Y. Koishihara, Y. Ohsugi, K. Kumaki, T. Taga, T. Kishimoto & T. Suda: Soluble interleukin-6 receptor triggers osteoclast formation by interleukin-6. Proc Natl Acad Sci USA 90, 11924-11928 (1993) 17. G. Passeri, G. Girasole, T. Markus, J. S. Abrams, S. C. Manolagas & R. L. Jilka: 17ß-estradiol regulates IL-6 production and osteoclast development in murine calvaria cell cultures. J Bone Miner Res 6, S263 (1991) 18. G. Girasole, R. L. Jilka, F. Passeri, S. Boswell, G. Boder, D. C. Williams & S. C. Manologas: 17ß-Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 89, 883-891 (1992) 19. R. L. Jilka, C. Hangoc, G. Girasole, G. Passeri, D. C. Williams, J. S. Abrams, B. Boyce, H. Broxmeyer & S. C. Manolagas: Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science 257, 88-91 (1992) 20. C. Miyaura, K. Kusano, T. Masuzawa, O. Chaki, Y. Onoe, M. Aoyagi, T. Sasaki, T. Tamura, Y. Koishihara, Y. Ohsugi & T. Suda: Endogenous bone-resorbing factors in estrogen deficiency: Cooperative effects of IL-1 and IL-6. J Bone Miner Res 10, 1365-1373 (1995) 21. V. Poli, R. Balena, E. Fattori, A. Markatos, M. Yamamoto, H. Tanaka, G. Ciliberto, G. Rodan & C. A: Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO 13, 1189-1196 (1994) 22. S. Tabibzadeh, Q. F. Kong, A. Babaknia & L. T. May: Progressive rise in the expression of intereleukin-6 in human endometrium during menstrual cycle is initiated during the implantation window. Mol Hum Reprod 1, 2793-2799 (1995) 23. S. S. Tabibzadeh, U. Santhanam, P. B. Sehgal & L. T. May: Cytokine-induced production of IFN-ß2/IL-6 by freshly explanted human endometrial stromal cells. Modulation by estradiol-17ß. J Immunol 142, 3134-3139 (1989) 24. H. Hakovirta, V. Syed, B. Jegou & M. Parvinen: Function of interleukin-6 as an inhibitor of meiotic DNA synthesis in the rat seminiferous epithelium. Mol Cell Endocrinol 108, 193-198 (1995) 25. J. G. Krueger, J. F. Krane, D. M. Carter & A. B. Gottlieb: Role of growth factors, cytokines, and their receptors in the pathogenesis of psoriasis. J Invest Dermatol 94(suppl), 135S-140S (1990) 26. R. M. Grossman, J. Kreuger, D. Yourish, A. Granelli-Piperno, D. P. Murphy, L. T. May, T. S. Kupper, P. B. Sehgal & A. B. Gottlieb: Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratin0cytes. Proc Natl Acad Sci USA 86, 6367-6371 (1989) 27. K. Yoshizaki, N. Nishimoto, K. Matsumoto, H. Tagoh, T. Taga, Y. Deguchi, T. Kuritani, T. Hirano, I. Hashimoto, N. Okada & T. Kishimoto: Interleukin-6 and eexpression of its receptor on epidermal keratinocytes. Cytokines 2, 381-387 (1990) 28. S. Navarro, N. Devili, J. P. LeCouedic, B. Klein, J. Bretonn-Gorius, J. Doly & W. Vainchenker: Interleukin-6 and its receptor are expressed by human megakaryocytes: In vitro effects on proliferation and endoreplication. Blood 77, 461-471 (1991) 29. W. H. Sun, N. Binkley, D. W. Bidwell & W. B. Ershler: The influence of recombinant human interleukin-6 on Blood and immune parameters in middle-aged and old rhesus monkeys. Lymphokine & Cytokine Research 12, 449-455 (1993) 30. R. J. Hill, M. K. Warren, P. Stenberg, H. Levin, L. Corash, R. Drummond, G. Baker, F. Levin & Y. Mok: Stimulation of megakaryocytopoiesis in mice by human recombinant interleukin-6. Blood 77, 42-48 (1991) 31. Y. Shabo, L. J, M. Rubinstein, M. Revel, S. C. Clark, S. F. Wolf, R. Kamen & L. Sachs: The myeloid Blood cell differentiation inducting protein MGI-2A is interleukin-6. Blood 72, 2070-2073 (1988) 32. C. P. Chiu, F. Lee, T. J. Fero, A. Johnson, J. Everitt & A. B. Malik: IL-6 is a differentiation factor for M1 and WEHI-3B myeloid leukemic cells. J Immunol 142, 1909-1915 (1989) 33. J. Lotem, Y. Shabo & L. Sachs: Clonal variation in susceptibility to differentiation by different protein inducers in the myeloid Leukemia cell line M1. Leukemia 3, 804-807 (1989) 34. T. Hama, M. Miyamoto, H. Tsukui, C. Nishio & M. Hatanaka: Interleukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci Lett 104, 340-344 (1989) 35. T. Satoh, S. Nakamura, T. Taga, T. Matsuda, T. Hirano, T. Kishimoto & Y. Kaziro: Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6. Mol Cell Biol 8, 3546-3549 (1988) 36. I. Tamm, I. Cardinale & P. Sehgal: Interleukin-6 and 12-O-tetradecanoyl phorbol-13-acetate act synergistically in inducing cell-cell separation and migration of human breast carcinoma cells. Cytokine 3, 212-223 (1991) 37. T. Ishibashi, Y. Shikama, H. Kimura, M. Kawaguchi, T. Uchida, T. Yamamoto, A. Okano, Y. Akiyama, T. Hirano, T. Kishimoto & Y. Maruyama: Thrombopoietic effects of interleukin-6 in long-term administration in mice. Exp Hematol 21, 640-646 (1993) 38. C. D. Ullmann, J. Schlom & J. W. Greiner: Interleukin-6 increases carcinoembryonic antigen and histocompatibility leukocyte antigen expression on the surface of human colorectal carcinoma cells. J Immunother 12, 231-241 (1992) 39. W. H. Sun, R. A. Kreisle, A. W. Philips & W. B. Ershler: In vivo and in vitro characteristics of interleukin 6-transfected B16 melanoma cells. Cancer Res 52, 5412-5415 (1992) 40. L. Chen, Y. Mory, A. Zilberstein & M. Revel: Growth inhibition of human breast carcinoma and Leukemia/lymphoma cell lines by recombinant interferon-beta2. Proc Natl Acad Sci USA 85, 8037 (1988) 41. J. J. MulŽ, M. C. Custer, W. D. Travis & S. A. Rosenberg: Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice. J Immunol 8, 2622-2629 (1992) 42. J. Serve, G. Steinhauser, D. Oberberg, W. A. Fiegel, J. Northoff & W. E. Berdel: Studies on the interaction between interelukin 6 and human malignant nonhematopoietic cell lines. Cancer Res 51, 3862-3866 (1991) 43. C. Lu & R. S. Kerbel: Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J Cell Biol 120, 1281-1288 (1993) 44. J. Fujita, J. Takenawa, Y. Kaneko, K. Okumura & O. Yoshida: Anti-interleukin-6 (IL-6) therapy of IL-6-producing renal cell carcinoma. Acta Urol Jpn 38, 1333-1336 (1992) 45. A. S. Koo, C. Armstrong, B. Bochner, T. Shimabukuro, C. Tso, J. B. deKernion & A. Belldegrun: Interleukin-6 and renal cell cancer: production, regulation, and growth effects. Cancer Immunol Immunother 35, 97-105 (1992) 46. P. H. Gumerlock & J. H. Li: Antisense inhibition of interleukin-6 production by and growth of human prostate cancer cells. Proc Annu Meet Am Assoc Cancer Res 34, A2950 (1993) 47. S. A. Miles, A. R. Rezai, J. F. Salazar-Gonzalez, M. V. Meyden, R. H. Stevens, D. M. Logan, R. T. Mitsuyasu, T. Taga, T. Hirano, Y. Kishimoto & O. Martinez-Maza: AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6. Proc Natl Acad Sci USA 87, 4068-4072 (1990) 48. S. Wu, K. Rodabaugh, O. Martinez-Maza, J. M. Watson, D. S. Silberstein, C. M. Boyer, W. P. Peters, J. B. Weinberg, J. S. Berek & R. C. Bast Jr: Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-a. Am J Obstet Gynecol 166, 997-1007 (1992) 49. S. Shimuzu, T. Hirano, R. Yoshioka, S. Sugai, T. Matsuda, T. Taga, T. Kishimoto & S. Konda: Interleukin 6 (B-cell stimulatory factor 2) dependent growth of a Lennert's lymphoma derived T-cell line (KT-3). Blood 72, 1826-1828 (1988) 50. C. A. Schirren, H. Volpel & S. C. Meuer: Spontaneous responsiveness to cytokines by human T-cell leukemias. Leukemia 6, 574-581 (1992) 51. B. Barut, D. Chauhan, H. Uchiyama & K. C. Anderson: Interleukin-6 functions as an intracellular growth factor in hairy cell leukemia in vitro. J Clin Invest 92, 2346-2352 (1993) 52. Y. Okuno, T. Takahashi, A. Suzuki, M. Fukumoto, K. Nakamura, H. Fukui, Y. Koishihara, Y. Ohsugi & H. Imura: Acquisition of growth autonomy and tumorigenicity by an interleukin 6-dependent human myeloma cell line transfected with interleukin 6 cDNA. Exp Hematol 20, 395-400 (1992) 53. M. Kawano, T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, H. Tanaka, A. Kuramoto & T. Kishimoto: Autocrine generation and requirement of BSF-2/IL-6 for human multiple myeloma. Nature 332, 83-85 (1988) 54. K. C. Anderson, R. M. Jones, C. Morimoto, P. Leavitt & B. A. Barut: Response patterns of purified myeloma cells to hematopoietic growth factors. Blood 73, 1915-1924 (1989) 55. M. Kawano, H. Tanaka, H. Ishikawa, M. Nobuyoshi, K. Iwato, H. Asaoku, O. Tanabe & A. Kuramato: Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma. Blood 73, 2145-2148 (1989) 56. B. Klein, X. Zhang, M. Jourdan, J. Content, F. Houssiau, L. Aarden, M. Pichaczyk & R. Bataille: Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 73, 517-526 (1989) 57. H. Jernberg, M. Pettersson, T. Kishimoto & K. Nilsson: Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA in a panel of established human multiple myeloma cell lines. Leukemia 5, 255-265 (1991) 58. O. Tanabe, M. Kawano, H. Tanaka, K. Iwato, H. Asaoku, H. Ishikawa, M. Nobuyoshi, T. Hirano, T. Kishimoto & A. Kuramoto: BSF-2/IL-6 does not augment Ig secretion but stimulates proliferation of myeloma cells. Am J Hematol 31, 258-262 (1989) 59. X. G. Zhang, B. Klein & R. Bataille: Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma. Blood 74, 11-13 (1989) 60. S. C. Manolagas: Role of Cytokines in bone resorption. Bone 17, 63S-67S (1995) 61. J. A. Lorenzo: The role of Cytokines in the regulation of local bone resorption. Crit Rev Immunol 11, 195-213 (1991) 62. G. D. Roodman, N. Kurihara, Y. Ohsaki, T. Kukita, D. Hosking, A. Demulder & F. R. Singer: Interleukin-6: a potential autocrine/paracrine factor in Paget's disease of bone. J Clin Invest 89, 46-52 (1992) 63. K. S. Black, G. R. Mundy & I. R. Garrett: Interleukin-6 causes hypercalcemia in vivo, and enhances the bone resorbing potency of interleukin-1 and tumor necrosis factor by two orders of magnitude in vitro. J Bone Miner Res 6, S271 (1991) 64. E. M. Greenfield, S. M. Shaw, S. A. Gornik & M. A. Banks: Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. J Clin Invest 96, 1238-1244 (1995) 65. C. W. G. M. Löwik, G. van der Pluijm, H. Bloys, K. Hoekman, O. L. M. Bijvoet, L. A. Asrden & S. E. Papapoulos: Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis. Biochem Biophys Res Comm 162, 1546-1552 (1989) 66. Y. Ishimi, C. Miyaura, C. H. Jin, T. Akatsu, E. Abe, Y. Nakamura, A. Yamaguchi, S. Yoshiki, T. Matsuda, T. Hirano, T. Kishimoto & T. Suda: IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145, 3297-3303 (1990) 67. Y. Ohsaki, S. Takahashi, T. Scarcez, A. Demulder, T. Nishihara, R. Williams & G. D. Roodman: Evidence for an autocrine/paracrine role for interleukin-6 in bone resorption by giant cells from giant cell tumors of bone. Endocrinology 131, 2229-2234 (1992) 68. J. De La Mata, H. L. Uy, T. A. Guise, B. Story, B. F. Boyce, G. R. Mundy & G. D. Roodman: Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest 95, 2846-2852 (1995) 69. W. B. Ershler, W. H. Sun & N. Binkley: The role of interleukin-6 in certain age-related diseases. Drugs Aging 5, 358-365 (1994) 70. W. B. Ershler: Interleukin-6: A cytokine for gerontologists. J Am Geriatr Soc 41, 176-181 (1993) 71. R. Weindruch: Caloric restriction and aging. Scientific American 274, 46-52 (1996) 72. M. J. Volk, T. D. Pugh, M. J. Kim, C. H. Frith, R. A. Daynes, W. B. Ershler & R. Weindruch: Dietary restriction from middle age attenuates age-associated lymphoma development and IL-6 dysregulation in C57BL/6 mice. Cancer Res 54, 3054-3063 (1993) 73. W. B. Ershler, W. H. Sun, N. Binkley, S. Gravenstein, M. J. Volk, G. Kamoske, R. G. Klopp, E. B. Roecker, R. A. Daynes & R. Weindruch: Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing age and in vitro production is modifiable by dietary restriction. Lymphokine Cytokine Res 12, 225-230 (1993) 74. W. Regelson, R. Loria & M. Kalimi: Hormonal intervention: "buffer hormones" or "state dependency". The role of dehydroepiandrosterone (DHEA), thyroid hormone, estrogen and hypophysectomy in aging. Ann NY Acad Sci 521, 260-273 (1988) 75. R. A. Daynes, B. A. Araneo, W. B. Ershler, C. Maloney, G. Z. Li & S. Y. Ryu: Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. J Immunol 150, 5219-5230 (1993) 76. G. Scala, M. R. Ruocco, C. Ambrosino, M. Mallardo, V. Giordano, F. Baldassarre, E. Dragonetti, I. Quinto & S. Venuta: The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein. J Exp Med 179, 961-971 (1994) 77. M. Honda, S. Yamamoto, M. Cheng, K. Yasukawa, H. Suzuki, T. Saito, Y. Osugi, T. Tokunaga & T. Kishimoto: Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection. J Immunol 148, 2175-2180 (1992) 78. S. Kotake, K. Sato, K. J. Kim, N. Takahashi, N. Udagawa, I. Nakamura, A. Yamaguchi, T. Kishimoto, T. Suda & S. Kashiwazaki: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids form rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res 11, 88-95 (1996) 79. J. T. Beck, S.-H. Jsu, J. Wijdenes, R. Bataille, B. Klein, D. Vesole, K. Hayden, S. Jagannath & B. Barlogie: Brief report: Alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. N Eng J Med 330, 602-605 (1994) 80. S. J. Brandt, D. M. Bodine, C. E. Dunbar & A. W. Nienhuis: Dysregulated interlukin 6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest 86, 592-599 (1990) 81. Y. Seino, U. Ikeda & K. Shimada: Increased expression of interleukin 6 mRNA in cardiac myxomas. Br Heart J 69, 565-567 (1993) 82. T. Kanda, S. Umeyama, A. Sasaki, Y. Nakazato, Y. Morishita, S. Imai, T. Suzuki & K. Murata: Interleukin-6 and cardiac myxoma. Am J Cardiol 74, 965-967 (1994) 83. J. R. Seguin, J. Y. Beigbeder, U. Hvass, J. Langlois, R. Grolleau, M. Jourdan, B. Klein, R. Bataille & P. A. Chaptal: Interleukin 6 production by cardiac myxomas may explain constitutional symptoms. J Thoracic Cardiovas Surg 103, 599-600 (1992) 84. A. Wagge, P. Brandtzaeg, A. Halstensen, P. Kierulf & T. Espevik: The complex pattern of Cytokines in serum from patients with meningococcal septic shock. J Exp Med 169, 333-338 (1989) 85. F. A. Houssiau, K. Bukasa, C. J. M. Sindic, J. Van Damme & J. Van Snick: Elevated levels of the 26k human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol 71, 320-323 (1988) 86. F. Houssiau, J. P. Devoglaer, J. Van Damme, C. Nagant de Deuxchaisnes & J. Van Snick: Interleukin 6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum 31, 784-788 (1988) 87. L. T. May, J. Grayeb, U. Santhanam, S. B. Tatter, Z. Sthoeger, D. C. Helfgott, N. Chiorazzi, G. Grieninger & P. B. Sehgal: Synthesis and secretion of multiple forms of b2-interferon/B-cell differentiation factor 2/hepatocyte-stimulating factor by human fibroblasts and monocytes. J Biol Chem 263, 7760-7766 (1988) 88. L. T. May, U. Santhanam, S. B. Tatter, D. C. Helfgott, A. Ray, J. Grayeb & P. B. Sehgal: Phosphorylation of secreted froms of human b2-interferon/hepatocyte-stimulating factor/interleukin-6. Biochem Biophys Res Commun 152, 1144-1150 (1988) 89. J. Van Snick: Interleukin-6: An overview. Annu Rev Immunol 8, 253-278 (1990) 90. J. Van Snick, S. Cayphas, J.-P. Szikora, J.-C. Renauld, E. Van Roost, T. Boon & R. J. Simpson: cDNA cloning of murine interleukin-HP1: homology with human interleukin-6. Eur J Immunol 18, 193-198 (1988) 91. N. Ida, S. Sakurai, T. Hosaka, K. Hosoi, T. Kunitomo, T. Shimazu, T. Maruyama & M. Kahase: Establishment of strongly neutralizing monoclonal antibody to human interleukin-6 and its epitope analysis. Biochem Biophys Res Commun 165, 728-734 (1989) 92. H. N. Snouwaert, K. Kariya & D. M. Fowlkes: Effects of site-specific mutations on biologic activities of recombinant human IL-6. J Immunol 146, 585-591 (1991) 93. A. Krüttgen, S. Rosejohn, C. Möller, B. Wroblowski, A. Wollmer, J. Müllberg, T. Hirano, T. Kishimoto & P. C. Heinrich: Structure-function analysis of human interleukin-6-Evidence for the involvement of the carboxy-terminus in function. FEBS Lett 262, 323-326 (1990) 94. J. P. Brakenhoff, M. Hart & L. A. Aarden: Analysis of human IL-6 mutants expressed in Escheria coli. Biologic activities are not affected by deletion of aminon acids 1-28. J Immunol 143, 1175-1182 (1989) 95. P. B. Sehgal, A. Zilberstein, M. R. Ruggieri, L. T. May, A. Ferguson-Smith, D. L. Sate, M. Revel & F. H. Ruddle: Human chromosome 7 carries the ß2 interferon gene. Proc Natl Acad Sci USA 83, 8957-8961 (1986) 96. A. M. Bowcock, J. R. Kidd, N. Lathrop, L. Daneshvar, L. T. Mary, A. Ray, P. B. Sehgal, K. K. Kidd & L. L. Cavalli-Sforza: The human "b2 interferon/hepatocyte stimulating factor/interleukin-6" gene: DNA polymorphism studies and localization to chromosome 7p21. Genomics 3, 8-16 (1988) 97. A. C. Ferguson-Smith, Y. F. Chen, M. S. Newman, L. T. May, P. B. Sehgal & F. H. Ruddle: Regional localization of the beta2-interferon/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21. Genomics 2, 203-208 (1988) 98. O. Tanabe, S. Akira, T. Kamiya, G. G. Wong, T. Hirano & T. Kishimoto: Genomic structure of the murine IL-6 gene: High degree of conservation of potential regulatory sequences between mouse and human. J Immunol 141, 3875-3881 (1988) 99. K. Yasukawa, T. Hirano, Y. Watanabe, K. Muratani, T. Matsuda, S. Nakai & T. Kishimoto: Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J 6, 2939-2945 (1987) 100. Y. Zhang, M. Broser & W. N. Rom: Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B. Proc Natl Acad Sci USA 91, 2225-2229 (1994) 101. O. Muraoka, T. Kaisho, M. Tanabe & T. Hirano: Transcriptonal activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappaB-like binding site. Immunol Letters 37, 159-165 (1993) 102. N. Mori, F. Shirakawa, H. Shimizu, S. Murakami, S. Oda, K. Yamamoto & S. Eto: Transcriptional regulation of the human interleukin-6 gene promoter in human T-cell leukemia virus type I-infected T-cell lines: evidence for the involvement of NF-kappa B. Blood 84, 2904-2911 (1994) 103. I. Yamashita, S. Katamine, R. Moriuchi, Y. Nakamura, T. Miyamoto, K. Eguchi & S. Nagataki: Transactivation of the human interleukin-6 gene by human T-lymphotropic virus type 1 Tax protein. Blood 84, 1573-1578 (1994) 104. S. F. Yan, I. Tritto, D. Pinsky, H. Liao, J. Huang, G. Fuller, J. Brett, L. May & D. Stern: Induction of interleukin 6 (IL-6) by hypoxia in vascular cells. Central role of the binding site for nuclear factor-IL-6. J Biol Chem 270, 11463-11471 (1995) 105. U. Dendorfer, P. Oettgen & T. A. Libermann: Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol Cell Biol 14, 4443-4454 (1994) 106. M. A. Brach, H. J. Gruss, T. Kaisho, Y. Asano, T. Hirano & F. Herrmann: Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B. J Biol Chem 268, 8466-72 (1993) 107. L. Margulies & P. B. Sehgal: Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBPß (NF-IL6) activity by p534 species. J Biol Chem 268, 15096-15100 (1993) 108. P. M. Janaswami, D. V. Kalvakolanu, Y. Zhang & G. C. Sen: Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins. J Biol Chem 267, 24886-24891 (1992) 109. M. A. Brach, S. de Vos, C. Arnold, H. J. Gruss, R. Mertelsmann & F. Herrmann: Leukotriene B4 transcriptionally activates interleukin-6 expression involving NK-chi B and NF-IL6. Eur J Immunol 22, 2705-11 (1992) 110. H. J. Gruss, M. A. Brach & F. Herrmann: Involvement of nuclear factor-kappa B in induction of the interleukin-6 gene by leukemia inhibitory factor. Blood 80, 2563-2570 (1992) 111. C. S. Yee, H. A. Messner & M. D. Minden: Regulation of interleukin-6 expression in the lymphoma cell line OCI-LY3. J Cell Physiol 148, 426-429 (1991) 112. Y. Zhang, J.-X. Lin & J. Vilcek: Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappa B-like sequence. Mol Cell Biol 10, 3818-3823 (1990) 113. H. Shimuzu, K. Mitomo, T. Watanbe, S. Okamoto & K. Yamamoto: Involvement of a NF-kB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Mol Cell Biol 10, 561-568 (1990) 114. U. Santhanam, A. Ray & P. B. Sehgal: Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc Natl Acad Sci USA 88, 7605-7609 (1991) 115. A. Ray, P. Sassone-Corsi & P. B. Sehgal: A multiple Cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: Similarities with c-fos gene regulation. Mol Cell Biol 9, 5537-5547 (1989) 116. A. Ray, K. E. Prefontaine & P. Ray: Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA estrogen receptor. J Biol Chem 269, 12940-12946 (1994) 117. S. T. Pottratz, T. Bellido, H. Mocharla, D. Crabb & S. C. Manolagas: 17b-Estradiol inhibits expression of human promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest 93, 944-950 (1994) 118. E. T. Keller, C. Chang & W. B. Ershler: Inhibition of NFkappaB activity through maintenance of IkappaBalpha levels contributes to dihydrotestosterone-mediated repression of the interleukin-6 promoter. J Biol Chem 271, 26267-26275 (1996) 119. A. Ray, K. S. LaForge & P. B. Sehgal: Repressor to activator switch by mutations in the the glucocorticoid receptor: Is direct DNA binding necessary? Proc Natl Acad Sci USA 88, 7086-7090 (1991) 120. A. Ray & K. E. Prefontaine: Physical association and functional antagonism between subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc Natl Acad Sci USA 91, 752-756 (1994) 121. R. J. Zitnik, N. L. Whiting & J. A. Elias: Glucocorticoid inhibition of interleukin-1-induced production by human lung fibroblasts: evidence for and post-transcriptional regulatory mechanisms. Am J Respir Cell Mol Biol 10, 643-650 (1994) 122. T. M. Fisch, R. Prywes & R. G. Roeder: c-fos sequences necessary for basal expression and induction by epidermal growth factor, 12-O-tetradecanoyl phorbol-13-acetate, and the calcium ionophore. Mol Cell Biol 7, 3490-3402 (1987) 123. M. Z. Gilman: The c-fos serum response element responds to protein kinase C-dependent and -independent signals but not to cyclic AMP. Genes Dev 2, 394-402 (1988) 124. P. Navarra, S. Tsagarakis, M. Faria, L. H. Rees, M. Besser & A. B. Grossman: Interleukin-1 and -6 stimulate the release of corticotropoin-releasing hormone from rat hypothalamus in vitro via eicosanoid cyclooxygenase pathway. Endocrinology 128, 37-44 (1990) 125. K. Lyson, K. Milenkovic & S. M. McCann: The stimulatory effect of interleukin-6 on corticotorpin-releasing factor and thyrotropin-releasing hormone secretion in vitro. Prog Neuroendocrinol Immunol 4, 161-165 (1991) 126. B. M. R. N. J. Woloski, E. M. Smith, W. J. Meyer III, G. M. Fuller & J. E. Blalock: Corticotropin-releasing activity in monokines. Science 230, 1035-1037 (1985) 127. M. Kohase, D. Henriksen-DiStefano, L. T. May & J. Vilcek: Dexamethasone inhibits feedback regulation of the mitogenic activity of tumor necrosis factor, interleukin-1 and epidermal growth factor in human fibroblasts. J Cell Physiol 132, 271-278 (1987) 128. H. J. M. Feyen, P. Elford, F. E. Ki Padova & U. Trechsel: Interleukin-6 is produced by bone and modulated by parathyroid hormone. J Bone Miner Res 4, 633-638 (1989) 129. T. Nishida, S. Nakai, T. Kawakami, K. Aihara, N. Nishino & Y. Hirai: Dexamethasone regulation of the expression of Cytokine mRNAs induced by interleukin-1 in the astrocytoma cell line U373MG. FEBS Lett 243, 25-29 (1989) 130. A. Ray, K. S. LaForge & P. B. Sehgal: On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: Enhancer, TATA box, and RNA start site (Inr Motif) occlusion. Mol Cell Biol 10, 5736-5746 (1990) 131. S. T. Smale, M. C. Schmidt, A. J. Berk & D. Baltimore: Transcriptional activation by Sp1 as directed throught the TATA or initiator: specific requirement for mammalian transcription factor IID. Proc Natl Acad Sci USA 87, 4509-4513 (1990) 132. M. I. Diamond, H. N. Miner, S. K. Yoshinaga & K. R. Yamamoto: Transcription factor interactions: selectors of positive or negative regulation form a single DNA element. Science 249, 1266-1272 (1990) 133. C. Jonat, H. J. Rahmsdorf, K.-K. Park, A. C. B. Cato, S. Gebel, H. Ponta & P. Herrlich: Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62, 1189-1204 (1990) 134. R. I. Scheinman, P. C. Cogswell, A. K. Lofquist & A. S. Baldwin Jr: Role of transcriptional activation of IkappaBalpha in mediation of immunosuppression by glucocorticoids. Science 270, 283-286 (1995) 135. N. Auphan, A. SiSonato, C. Rosette, A. Helmberg & M. Karin: Immunosuppression by glucocorticoids: Inhibition of NF-kB activity through induction of IkappaB synthesis. Science 270, 286-2290 (1995) 136. D. M. Kania, N. Binkley, M. Checovich, T. Havighurst, M. Schilling & W. B. Ershler: Elevated plasma levels of interleukin-6 in postmenopausal women do not correlate with bone density. J Am Geriat Soc 43, 236-239 (1995) 137. S. H. Ralston: Analysis of gene expression in human bone biopsies by polymerase chain reaction: evidence for enhanced Cytokine expression in post-menopausal osteoporosis. J Bone Miner Res 9, 883-890 (1994) 138. R. Pacifici, C. Brown, E. Puscheck, E. Friedrich, E. Slatopolsky, D. Maggio, R. McCracken & L. V. Avioli: Effect of surgical menopause and estrogen replacement on Cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA 88, 5134-5138 (1991) 139. G. Pioli, G. Basini, M. Pedtazzoni, G. Musetti, V. Ulietti, D. Bresciani, P. Villa, A. Bacchi, D. Hughes, M. Russel & M. Passeri: Spontaneous release of interleukin-1 and interleukin-6 by peripheral blood mononuclear cells after oophorectomy. Clin Sci 83, 503-507 (1992) 140. M. Kassem, S. A. Harris, T. C. Spelsberg & R. B. L: Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptor. J Bone Miner Res 11, 193-199 (1996) 141. B. Stein & M. X. Yang: Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappaB and C/EBPß. Mol Cell Biol 15, 4971-4979 (1995) 142. S. Leppa, P. Härkönen & M. Jaikanen: Steroid-induced epithelial-fibroblastic conversion associated with syndecan suppression in S115 mouse mammary cells. Cell Regul 2, 1-11 (1991) 143. P. V. Bodine, B. L. Riggs & T. C. Spelsberg: Regulation of c-fos expression and TGF-beta production by gonadal and adrenal androgens in normal human osteoblastic cells. J Steroid Biochem Mol Biol 52, 149-158 (1995) 144. E. W. Bingaman, D. J. Magnuson, T. S. Gray & R. J. Handa: Androgen inhibits the increases in hypothalamic corticotropin-releasing hormone (CRH) and CRH-immunoreactivity following gonadectomy. Neuroendocrinology 59, 228-234 (1994) 145. C. M. Clay, R. A. Keri, A. B. Finicle, L. L. Heckert, D. L. Hamernik, K. M. Marschke, E. M. Wilson, F. S. French & J. H. Nilson: Transcriptional repression of the glycoprotein hormone alpha subunit gene by androgen may involve direct binding of androgen receptor to the proximal promoter. J Biol Chem 268, 13556-13564 (1993) 146. A. Mizokami, H. Saiga, T. Matsui, T. Mita & A. Sugita: Regulation of androgen receptor by androgen and epidermal growth factor in a human prostatic cancer cell line, LNCaP. Endocrinologia Japonica 39, 235-43 (1992) 147. M. A. Mancini, B. Chatterjee & A. K. Roy: Age-dependent reversal of the lobular distribution of androgen-inducible alpha 2u globulin and androgen-repressible SMP-2 in rat liver. J Histochem Cytochem 39, 401-5 (1991) 148. H. Persson, C.-L. Lievre, O. Söder, M. J. Villar, M. Metsis, L. Olson, M. Ritzen & T. Hökfelt: Expression of b-nerve growth factor receptor mRNA in Sertoli cells is downregulated by testosterone. Science 247, 704-707 (1990) 149. M. Metsis, T. Timmusk, R. Alikmets, M. Saarma & H. Persson: Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter. Gene 121, 247-254 (1992) 150. P. J. Kallio, H. Poukka, A. Moilanen, O. A. JŠnne & J. J. Palvimo: Androgen receptor-mediated transcriptional regulation in the absence of direct interaction with a specific DNA element. Mol Endocrinol 9, 1017-1028 (1995) 151. M. L. Montpetit, K. R. Lawless & M. Tenniswood: Androgen-repressed messages in the rat ventral prostate. The Prostate 8, 25-36 (1986) 152. R. Buttyan, Z. Zakeri, R. Lockshin & D. Wolgemuth: Cascade induction of c-fos, c-myc, and heat shock 70K transcripts during regression of the rat ventral prostate gland. Mol Endocrinol 2, 650-657 (1988) 153. M. L. Day, S. Wu & J. W. Basler: Prostate nerve growth factor inducible A gene binds a novel element in the retinoblastoma gene promoter. Cancer Res 53, 5597-5599 (1993) 154. D. A. Wolf, F. Kohlhuber, P. Schulz, F. Fittler & D. Eick: Transcriptional down-regulation of c-myc in human prostate carcinoma cells by the synthetic androgen mibolerone. Br J Cancer 65, 376-382 (1992) 155. P. Wong, J. Pineault, J. Lakins, D. Taillefer, J. LŽger, C. Wang & M. Tenniswood: Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis. J Biol Chem 268, 5021-5031 (1993) 156. J. Lindzey, M. Grossmann, M. V. Kumar & D. J. Tindall: Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen. Mol Endocrinol 7, 1530-1540 (1993) 157. V. E. Quarmby, W. C. Beckman, E. M. Wilson & F. S. French: Androgen regulation of c-myc messenger ribonucleic acid levels in rat ventral prostate. Mol Endocrinol 1, 865-874 (1987) 158. T. Bellido, R. L. Jilka, B. F. Boyce, G. Girasole, H. Broxmeyer, S. A. Dalrymple, R. Murray & S. C. Manolagas: Regulation of interleukin-6, osteoclastogenesis, and Bone mass by androgens. The role of the androgen receptor. J Clin Inv 95, 2886-2895 (1995) 159. T. T. Hung & W. E. Gibbons: Evaluation of androgen antagonism of estrogen effect by dihydrotestosterone. J Steroid Biochem 19, 1513-1520 (1983) 160. E. P. Smith, J. Boyd, G. R. Frank, H. Takahashi, T. M. Cohen, B. Specker, T. C. Williams, D. B. Lubahn & K. S. Korach: Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Eng J Med 331, 1056-1061 (1994) 161. S. Eriksson, A. Eriksson, R. Stege & K. Carlström: Bone mineral density in patients with prostatic cancer treated with orchidectomy and with estrogens. Calcif Tissue Int 57, 97-99 (1995) 162. K. Yamasaki, T. Taga, Y. Hirata, H. Yawata, Y. Kawanzihi, B. Seed, T. Taniguchi, T. Hirano & T. Kishimoto: Cloning and expression of the human interleukin-6 (BSF-2/IFNß 2) receptor. Science 241, 825-828 (1988) 163. H. Schooltink, T. Stoyan, D. Lenz, H. Schmitz, T. Hirano, T. Kishimoto, P. Henrich & S. Rose-John: Structural and functional studies on the human hepatic interleukin-6 receptor. Biochem J 277, 659-664 (1991) 164. P. M. C. Kluck, J. Wiegant, R. P. M. Hansen, M. W. J. Bolk, A. K. Raap, R. Willemze & J. E. Landegent: The human interleukin-6 receptor a chain gene is localized on chromosome 1 band q21. Hum Genet 90, 542-544 (1993) 165. M. Baumann, H. Baumann & G. H. Fey: Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor. J Biol Chem 265, 19853-19862 (1990) 166. J. F. Bazan: A novel family of growth factor receptors: a common binding domain in the growht hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor ß-chain. Biochem Biophys Res Commun 164, 788-795 (1989) 167. D. Cosman, S. D. Lyman, R. L. Idzerda, M. P. Beckmann, L. S. Park, R. G. Goodwin & C. J. March: A new Cytokine receptor superfamily. Trends Biol Sci 15, 265-270 (1990) 168. T. Taga, M. Hibi, M. Murakami, M. Saito, H. Yawata, T. Hirano & T. Kishimoto: Interleukin-6 receptor and signals. In: Interleukins: Molecular Biology and Immunology. Chem Immunol. (T. Kishimoto, ed.), Vol. 51, pp. 181-204. Basel, Karger 1992. 169. T. Taga, M. Hibi, Y. Hirata, K. Yamasaki, K. Yasukawa, T. Matsuda, T. Hirano & T. Kishimoto: Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp 130. Cell 58, 573-581 (1989) 170. M. Murakami, M. Hibi, N. Nakagawa, T. Nakagawa, K. Yasukawa, K. Yamanishi, T. Taga & T. Kishimoto: IL-6-induced homodimerization of gp 130 and associated activation of a tyrosine kinase. Science 260, 1808-1810 (1993) 171. L. D. Ward, G. J. Howlett, G. Discolo, K. Yasukawa, A. Hammacher, R. L. Moritz & R. J. Simpson: High affinity interleukin-6 receptor is a hexameric consisting of two molecules each of interleukin-6, receptor, and gp-130. J Biol Chem 269, 23286-23289 (1994) 172. H. Yawata, K. Yasukawa, S. Natsuka, M. Murakami, K. Yamasaki, M. Hibi, T. Taga & T. Kishimoto: Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130. EMBO J 12, 1705-1712 (1993) 173. D. Novick, H. Englmann, D. Wallach & M. Rubinstein: Soluble Cytokine receptors are present in normal human urine. J Exp Med 170, 1409-1414 (1989) 174. J. A. Lust, D. F. Jelinek, K. A. Donovan, L. A. Frederick, B. K. Huntley, J. K. Braaten & N. J. Maihle: Sequence, expression and function of an mRNA encoding of the human interleukin-6 receptor (sIL-6R). Curr Topics Microbiol Immunol 194, 199-205 (1994) 175. J. Mullberg, J. Schooltink, T. Stoyan, M. Gunther, L. Graeve, G. Buse, A. Mackiewicz, P. C. Henrich & S. Rose-John: The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol 23, 473-480 (1993) 176. T. Nakajima, S. Yamamoto, M. Cheng, K. Yasukawa, T. Hirano, T. Kishimoto, T. Tokunaga & M. Honda: Soluble interleukin-6 receptor is released from receptor-bearing cell line in vitro. Jpn J Cancer Res 83, 373-378 (1992) 177. P. B. Sehgal, L. Wang, R. Rayanade, H. Pan & L. Margulies: Interleukin-6 type Cytokines. In: Interleukin-6-type Cytokines. (A. Mackiewicz, A. Koji and P. B. Sehgal, eds.), Vol. 762, pp. 1-14. New York Academy of Sciences, New York 1995. 178. L. Snyers, V. Fontaine & J. Content: Modulation of interleukin-6 receptors in human cells. Ann NY Acad Sci 557, 388-393 (1989) 179. J. E. Nesbitt & G. M. Fuller: Differential regulation of interleukin-6 receptor and gp130 gene expression in rat hepatocytes. Mol Cell Biol 3, 103-112 (1992) 180. R. Hoffmann, H. P. Henninger, A. Schulze-Specking & K. Decker: Regulation of interleukin-6 receptor expression in rat cells: modulation by Cytokines, dexamethasone and. J Hepatol 21, 543-550 (1994) 181. J. Bauer, T. M. Bauer, T. Kalb, T. Taga, G. Lengyel, T. Joramp, T. Kishimoto, G. Acs, L. Mayer & W. Gerok: Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. J Exp Med 170, 1537-1549 (1989) 182. S. Rose-John, E. Hipp, D. Lenz, L. G. LegrŽs, H. Korr, T. Hirano, T. Kishimoto & P. C. Heinrich: Structural and functional studies on the human interleukin-6 receptor. J Biol Chem 266, 3841-3846 (1991) 183. L. Snyers, L. De Witt & J. Content: Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells. Proc Natl Acad Sci USA 87, 2838-2842 (1990) 184. S. Marinkovic & H. Baumann: Structure, hormonal regulation, and identification of the interleukin-6- and dexamethasone-responsive element of the rat haptoglobin gene. Mol Cell Biol 10, 1573-1583 (1990) 185. E. T. Keller & W. B. Ershler: Effect of IL-6 receptor antisense oligodeoxynucleotides on in vitro proliferation of myeloma cells. J Immunol 154, 4091-4098 (1995) 186. M. Portier, D. Lees, E. Caron, M. Jourdan, J. Boiron, R. Bataille & B. Klein: Up-regulation of interleukin (IL)-6 receptor gene expression in vitro and in vivo in IL-6 deprived myeloma cells. FEBS Lett 302, 35-38 (1992) 187. R. A. Gadient & U. Otten: Differential expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat hypothalamus. Neurosci Lett 153, 13-16 (1993) 188. R. A. Gadient & U. Otten: Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development. Brain Res 637, 10-14 (1994) 189. M. Jücker, H. Abts, W. Li, R. Schindler, H. Merz, A. Günther, C. von Kalle, M. Schaadt, T. Diamantstein, A. C. Feller, G. R. F. Krueger, B. Diehl, T. Blankenstein & H. Tesch: Expression of interleukin-6 and interleukin-6 receptor in Hodgkin's disease. Blood 77, 2413-2418 (1991) 190. F. J. Meyers, P. H. Gumerlock, E. S. Kawasaki, A. M. Wang, R. W. deVere White & H. A. Erlich: Human leuckocyte antigen II, interleukin-6, and interleukin-6 receptor expression determined by the polymerase chain reaction. Cancer 67, 2087-2095 (1991) 191. M. J. Siegsmund, H. Yamazki & I. Pastan: Interleukin 6 receptor mRNA in prostate carcinomas and benign prostate hyperplasia. J Urology 151, 1396-1399 (1994) 192. A. Silvani, G. Ferrari, G. Paonessa, C. Toniatti, G. Parmiani & M. P. Colombo: Down-regulation of interleukin 6 receptor a chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M. Cancer Res 55, 2200-2205 (1995) 193. A. J. Littlewood, J. Russell, G. R. Harvery, D. E. Hughes, R. G. G. Russell & M. Gowen: The modulation of the expression of IL-6 and its receptor in human osteoblasts in vitro. Endocrinology 129, 1513-1520 (1991) 194. H. Suzuki, K. Yasukawa, T. Saito, M. Narazaki, A. Hasegawa, T. Taga & T. Kishimoto: Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur J Immunol 23, 1078-1082 (1993)
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