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MOLECULAR AND CELLULAR BIOLOGY OF INTERLEUKIN-6 AND ITS RECEPTOR
Evan T. Keller1,2,3, Jon Wanagat1, W.B. Ershler1,3
1Glennan Center for Geriatrics and Gerontology, Departments of 2Pathology and 3Internal Medicine, Eastern Virginia Medical School.
Received 10/21/96; Accepted 11/01/96; On-line //96
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. An overview of interleukin-6
- 3.1. Physiology and pathophysiology of interleukin-6
- 3.2. Interleukin-6 structure and function
- 3.3. Control of interleukin-6 promoter activity
- 4. Steroids and regulation of interleukin-6 expression
- 4.1. Glucocorticoid and interleukin-6 expression
- 4.2. Estrogen and interleukin-6 expression
- 4.3. Androgen and interleukin-6 expression
- 5. The interleukin-6 receptor
- 5.1. The interleukin-6 receptor: Structure and function
- 5.2. Expression of the interleukin-6 receptor
- 6. Summary
- 7. Acknowledgments
- 8. References
- 9. Entire manuscript
Keywords: Gerontology, Immunology, Cytokines, Interleukin-6, Interleukin-6 receptor gp80, osteoporosis, prostate cancer
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