Rajesh K. Naz

Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio, USA

Received 07/23/96; Accepted 07/30/96; On-line 08/15/96

1. A. Ullrich. & J. Shlessinger: Signal transduction by receptors with tyrosine kinase activity. Cell 61,203-12 (1990)

2. T. Pawson: Protein modules and signalling network. Nature 373, 573-80 (1995)

3. J.A.Smith, S.H. Francis, & J.D. Corbin : Autophosphorylation: a salient feature of protein kinases. Mol Cell Biol 127/128, 51-70 (1993)

4. R. Yanagimachi: Mammalian fertilization. Eds: Knobil E, Neill JD, eds. Inc. The Physiology of Reproduction: Raven Press, New York 189-318 (1994)

5. R.K. Naz, N.J. Alexander, M. Isahakia, & M.D. Hamilton: Monoclonal antibody to a human sperm membrane glycoprotein that inhibits fertilization. Science 225, 342-344 (1984)

6. R. K. Naz, T. M. Phillips, & B. B.Rosenblum: Characterization of the fertilization antigen-1 for the development of a contraceptive vaccine. Proc Natl Acad Sci USA 83, 5713-17 (1986)

7. R. K. Naz, A. Sacco, O. Singh , R. Pal, & G. P. Talwar: Development of contraceptive vaccines for humans using antigens derived from gametes (spermatozoa and zona pellucida) and hormones (human chorionic gonadotrophin): current status. Hum Reprod Update 1:1-18 (1995)

8. P. Kaplan, & R.K. Naz: The fertilization antigen-1 does not have any proteolytic/acrosin activity, but its monoclonal antibody inhibits sperm capacitation and acrosome reaction. Fertil Steril 58, 396-402 (1992)

9. R.K. Naz, P. Kaplan, & A.L. Goldstein: Thymosin alpha-1 enhances the fertilizing capacity of human sperm cell: implication in diagnosis and treatment of male infertility. Biol Reprod 47, 1064-72 (1992)

10. R.K. Naz, K. Ahmad, & P. Kumar: Role of membrane phosphotyrosine proteins in human spermatozoal function. J Cell Sci 99, 157-65 (1991)

11. K. Ahmad & R.K. Naz : Thymosin alpha-1 and FA-1 monoclonal antibody affect fertilizing capacity of human sperm by modulating protein phosphorylation pattern. J Reprod Immunol 29, 1-17 (1995)

12. G. Todderud, M.I. Wahl, S.G. Rhee & G. Carpenter: Stimulation of phospholipase C-r₁ membrane association by epidermal growth factor. Science 249, 296-98 (1990)

13. R.L. Huganir, A.H. Delcour, P. Greengard & G.P. Hess: Phosphorylation of the nicotine acetylcholine receptor regulates its rate of desensitization. Nature 321, 774-76 (1986)

14. R. K. Naz & K. Ahmad: Molecular identities of human sperm proteins that bind human zona pellucida: nature of sperm-zona interaction, tyrosine kinase activity and involvement of FA-1. Mol Reprod Develop 39,397-408 (1994)

15. A. L. Kadam, M. Fateh & R.K. Naz: Fertilization antigen (FA-1) completely blocks human sperm binding to human zona pellucida: FA-1 antigen may be sperm receptor for zona pellucida in humans. Reprod Immunol 29, 19-30 (1995)

16. R. K. Naz, C. Brazil & J. W. Overstreet: Effects of antibodies to sperm surface fertilization antigen-1 on human sperm-human zona interaction. Fertil Steril 57, 1304-10 (1992)

17. R.K. Naz, A.G. Sacco, & E. C.Yurewicz: Human spermatozoal FA-1 binds with ZP3 of porcine zona pellucida. J Reprod Immunol 20, 43-58 (1991)

18. R. K. Naz, C. Morte, V. Garcia-Framis, P. Kaplan, & P. Martinez: Characterization of a sperm-specific monoclonal antibody and isolation of a 95-kilodalton fertilization antigen-2 from human sperm. Biol Reprod 49,1236-44 (1993)

19. L. Leyton, P. LeGuen, D. Bunch & P. M. Saling: Regulation of mouse gamete interaction by sperm tyrosine kinase. Proc Natl Acad Sci USA 89, 11692-95 (1992)

20. L. Leyton & P.M. Saling : 95 kD sperm protein binds ZP3 and serves as tyrosine kinase substrate in response to zona binding. Cell 57, 1123-30 (1989)

21. E. D. Duncan & L. R. Fraser: Cyclic AMP-dependent phosphorylation of epididymal mouse sperm proteins during capacitation in vitro: Identification of an Mr 95,000 phosphotyrosine-containing protein. J Reprod Fertil 97, 287-99 (1993)

22. E. Baldi, C. Falsetti, G. Gervasi, V. Carloni, R. Casano & G. Forti: Stimulation of platelet aggregation factor synthesis by progesterone and A23187 in human spermatozoa. Biochem J 292,209-16 (1992)

23. J. Tesarik, J. Moos & C. Mendoza: Stimulation of protein tyrosine phosphorylation by a progesterone receptor on the cell surface of human sperm. Endocrinology 133, 328-35 (1993)

24. R. K. Naz, B. B. Rosenblum , & A. C. Menge: Characterization of a membrane antigen from rabbit testes and sperm isolated by using monoclonal antibodies and effect of its antiserum on fertility. Proc Natl Acad Sci USA 81, 857-861 (1984)

25. M. S. Liu, R. Abersold, C. H. Fann & C.-Y. G.Lee: Molecular and development studies of a sperm acrosome antigen recognized by HS-63 monoclonal antibody. Biol Reprod 46, 937-48 (1992)

26. W. E. Lathrop, E. P. Carmichael, D. G. Myles & P. Primakoff: cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20 involved in sperm-egg adhesion and the wide distribution of its gene among mammals. J Cell Biol 42, 693-701 (1990)

27. M. G. O'Rand: Sperm-egg recognition and barriers to interspecies fertilization. Gamete Res 19, 315-28 (1988)

28. X. Zhu & R. K. Naz. Sequence homology among sperm antigens involved in mammalian fertilization: Search for a common epitope for immunocontraception. Arch. Androl. 33, 141-4 (1994)

29. R. K. Naz, M. M. Chaturvedi & B. B. Aggarwal: Role of cytokines and proto-oncogenes in sperm cell function: relevance to immunologic infertility. Am J Reprod Immuno 32, 26-7 (1994)

30. R. K. Naz & E. R. Stanley: Enhanced levels of colony stimulating factor-1 (CSF-1) in sera and seminal plasma of antisperm antibody-positive infertile men. Arch Androl 35, 5-11 (1995)

31. R. Paradisi, M. Capelli, M. Mandini, E. Bellavia, M. Focacci, & C. Flamigni: Interleukin-2 in seminal plasma of fertile and infertile men. Arch Androl 35, 35-42 (1995)

32. M. Rajasekaran, W. J. G. Hellstrom, R. K. Naz & S. C. Sikka: Oxidative stress and interleukins in seminal plasma during leukocytospermia. Fertil Steril 64, 166-71 (1995)

33. K. Shimoya, N. Matsuzaki, T. Tsutsui, T. Taniguchi, F. Saji & O. Tanizawa: Detection of interleukin-8 (IL-8) in seminal plasma and elevated IL-8 in seminal plasma of infertile patients with leukospermia. Fertil Steril 59, 885-88 (1993)

34. F. Hussenet, B. Dousset, J. L. Cordonnier, C. Jacob, B. Foliquet & G. Grignon: Tumor necrosis factor alpha and interleukin-2 in normal and infected seminal plasma. Hum Reprod 8, 409-11 (1993)

35. R. K. Naz & P. Kaplan: Increased levels of interleukin-6 in seminal plasma of infertile men. J Androl 15, 220-27 (1994)

36. R. K. Naz & P. Kaplan: Interleukin-6 enhances the fertilizing capacity of human sperm by increasing capacitation and acrosome reaction. J Androl 15, 228-33 (1994)

37. R. K. Naz & P. Kaplan: Effects of epidermal growth factor on human sperm cell function. J Androl 5, 240-47 (1993)

38. R. K. Naz, A. Butler, B. R. Witt, D. Barad & A. C. Menge: Levels of interferon-gamma and tumor necrosis factor- in sera and cervical mucus of fertile and infertile women: Implication in infertility. J Reprod Immunol 29, 105-17 (1995)

39. R. K. Naz & A. Butler: Interleukin-6 and -8 levels in sera and cervical mucus of fertile, idiopathic infertile and immunofertile and immunoinfertile women: Implication in infertility. Am J Reprod Immunol 35, 534-40 (1996)

40. R. K. Naz & K. Ahmad : Presence of expression products of c-erbß-1 and c-erbß-2/HER2 genes on mammalian sperm cell, and effects of their regulation on fertilization. J Reprod Immunol 21, 223-39 (1992)

41. I. Laursen, P. Briand & A. E. Lykkesfeldt: Serum albumin as a modulator on growth of the human breast cancer cell line, MCF-7. Anticancer Res 10, 343-51 (1990)

42. R. K. Naz & R. Kumar: Transforming growth factor ß, enhances expression of 50 kDa protein related to 2¹-5¹ oligonucleotide synthetase in human sperm cells. J Cell Physiol 146, 143-56 (1991)

43. G. Kumar, D. Patel & R. K. Naz: c-myc mRNA is present in human sperm cells. Cell Mol Biol Res 39, 111-17 (1993)

44. R. Roten , G. F. Paz , Z. T. Hamonnai, M. Kalina & Z. Naor: Protein kinase C is present in human sperm: possible role of flagellar motility. Proc Natl Acad Sci USA 87, 7305-08 (1990)

45. G. Kopf: Mechanisms of signal transduction in mouse sperm. Ann NY Acad Sci 564, 289-302 (1989)

46. R. K. Naz, K. Ahmad & P. Kaplan: Expression and function of ras-proto-oncogene proteins in human sperm cells. J Cell Sci 102, 487-94 (1992)

47. R. K. Naz, K. Ahmad & G. Kumar: Presence and role of c-myc proto-oncogene product in mammalian sperm cell function. Biol Reprod 44, 842-50 (1991)

48. R. K. Naz, K. Ahmad & P. Kaplan: Involvement of cyclins and cdc2 serine/threonine protein kinase in human sperm cell function. Biol Reprod 48, 720-28 (1993)

49. R. K. Naz. Protein tyrosine phosphorylation and signal transduction during capacitation/ acrosome reaction and zona pellucida binding in human sperm. Arch. Androl., 37, 47-55 (1996)