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INVOLVEMENT OF PROTEIN TYROSINE PHOSPHORYLATION OF HUMAN SPERM
IN CAPACITATION/ACROSOME REACTION AND ZONA PELLUCIDA BINDING
Rajesh K. Naz
Division of Research, Department of Obstetrics and Gynecology,
Medical College of Ohio, Toledo, Ohio, USA
Received 07/23/96; Accepted 07/30/96; On-line 08/15/96
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Discussion
- 3.1. Membrane tyrosine phosphorylation during spontaneous
capacitation/acrosome reaction
- 3.1.1. Effect of T1
- 3.1.2. Effect of anti-FA-1 monoclonal antibody
- 3.2. Membrane tyrosine phosphorylation involved in zona pellucida
binding
- 3.2.1. Molecular identities and tyrosine phosphorylation
of sperm proteins
- 3.2.2. FA-1 antigen is a sperm receptor for zona pellucida
- 3.2.3. The 95 kD and 51 kD (FA-1 antigen) sperm proteins
- 4. Conclusions
- 5. Acknowledgments
- 6. References
- 7. Entire manuscript
Key words: Sperm, tyrosine phosphorylation, tyrosine kinase,
signal transduction, capacitation, acrosome reaction, fertilization
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