[Frontiers in Bioscience 1, d206-213, August 15, 1996]
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CAVEAT LECTOR



INVOLVEMENT OF PROTEIN TYROSINE PHOSPHORYLATION OF HUMAN SPERM IN CAPACITATION/ACROSOME REACTION AND ZONA PELLUCIDA BINDING

Rajesh K. Naz

Division of Research, Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo, Ohio, USA

Received 07/23/96; Accepted 07/30/96; On-line 08/15/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. Membrane tyrosine phosphorylation during spontaneous capacitation/acrosome reaction
3.1.1. Effect of T1
3.1.2. Effect of anti-FA-1 monoclonal antibody
3.2. Membrane tyrosine phosphorylation involved in zona pellucida binding
3.2.1. Molecular identities and tyrosine phosphorylation of sperm proteins
3.2.2. FA-1 antigen is a sperm receptor for zona pellucida
3.2.3. The 95 kD and 51 kD (FA-1 antigen) sperm proteins
4. Conclusions
5. Acknowledgments
6. References
7. Entire manuscript

Key words: Sperm, tyrosine phosphorylation, tyrosine kinase, signal transduction, capacitation, acrosome reaction, fertilization