[Frontiers in Bioscience 1, d1-11, January 1, 1996]
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PubMed
CAVEAT LECTOR



THE MOLECULAR BASIS OF OVARIAN CELL DEATH DURING GERM CELL ATTRITION, FOLLICULAR ATRESIA, AND LUTEOLYSIS

Jonathan L. Tilly, Ph.D.

The Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School,Boston, MA 02114 USA

Received 12/14/95; Accepted 12/29/95; On-line 1/1/96



Key Words: Apoptosis, Cell Death, Ovary, Follicle, Oocyte, Granulosa Cell, Luteal Cell, Atresia, Luteolysis.

TABLE OF CONTENTS

1. Abstract
2. Physiological Cell Death: Mechanisms and Genes
2.1. Introduction
2.2. The bcl-2 Gene Family
2.3. Reactive Oxygen Species
2.4. Transcriptional Regulators
2.5. Cytoplasmic Proteases
3. Mechanisms and Effectors of Cell Death in the Ovary
3.1. Peri-Natal Germ Cell Attrition
3.1.1. Identification of Physiological Cell Death in Germ Cells
3.1.2. Hormonal Control of Germ Cell Survival
3.1.3. Intracellular Effectors of Survival Signals in Germ Cells
3.2. Post-Natal Follicular Atresia
3.2.1. Occurrence and Hormonal Regulation of Apoptosis in Follicles
3.2.2. The bcl-2 Gene Family and Follicular Atresia
3.2.3. Oxidative Stress During Atresia
3.2.4. Transcriptional Regulators in Granulosa Cells
3.2.5. Protease Activation During Apoptosis in Granulosa Cells
3.3. Regression of the Corpus Luteum (CL)
3.3.1. Cell Death in the CL
3.3.2. Control of Cell Death During Luteolysis
4. Conclusions
5. References
6. Acknowledgments
7. Entire manuscript