Yasuhito Abe, M.D.

The Second Department of Surgery, Ehime University School of Medicine, Shigenobu, Ehime 791-02, Japan

Received 05/15/96; Accepted 06/12/96; On-line 07/01/96

In patients with hemophilia, the use of HunIg has been associated with iatrogenic infections such as infection by retroviruses. The most effective way for prevention of transmission of infectious microorganisms, by plasma preparations including natural immuno-globulin is heat-treatment of these preparations (84).