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ASSESSMENT OF SPERM FUNCTION AND CLINICAL ASPECTS OF IMPAIRED
SPERM FUNCTION
Dana A. Ohl, M.D.1 and Alan C. Menge, Ph.D.2
1 Section of Urology, 1500 E. Medical Center Drive, Ann Arbor,
MI 48109-0330
2 F4826 Mott Hospital, 1500 East Medical Center
Drive, Ann Arbor, MI 48109-0272
Received 07/31/96; Accepted 07/31/96; On-line 09/01/96
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Summary of normal sperm function
- 4. Assessment of sperm function
- 4.1. Semen analysis
- 4.1.1. Sperm concentration:
- 4.1.2. Sperm motility:
- 4.1.3. Sperm morphology:
- 4.2. Sperm survival/longevity studies
- 4.3. Hypo-osmotic swelling test
- 4.4. Cervical mucus migration assay
- 4.5. Tests of Capacitation: hyperactivation, acrosome reaction,
acrosin assays
- 4.6. Human sperm penetration assay (SPA) with zona-free hamster
eggs
- 4.7. Hemizona binding assay
- 4.8. Antisperm antibody assays
- 4.9. In vitro fertilization (IVF), Intracytoplasmic sperm
injection (ICSI)
- 5. Selected clinical male infertility syndromes with impairment
of sperm function
- 5.1. Antisperm antibodies
- 5.2. Immotile cilia syndrome
- 5.3. Spinal cord injury/anejaculatory infertility
- 5.4. Nifedipine-associated Infertility
- 6. Therapies and future directions
- 7. References
- 8. Entire manuscript
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