[Frontiers in Bioscience 1, e96-108, September 1,1996]
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PubMed
CAVEAT LECTOR



ASSESSMENT OF SPERM FUNCTION AND CLINICAL ASPECTS OF IMPAIRED SPERM FUNCTION

Dana A. Ohl, M.D.1 and Alan C. Menge, Ph.D.2

1 Section of Urology, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0330

2 F4826 Mott Hospital, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0272

Received 07/31/96; Accepted 07/31/96; On-line 09/01/96

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Summary of normal sperm function
4. Assessment of sperm function
4.1. Semen analysis
4.1.1. Sperm concentration:
4.1.2. Sperm motility:
4.1.3. Sperm morphology:
4.2. Sperm survival/longevity studies
4.3. Hypo-osmotic swelling test
4.4. Cervical mucus migration assay
4.5. Tests of Capacitation: hyperactivation, acrosome reaction, acrosin assays
4.6. Human sperm penetration assay (SPA) with zona-free hamster eggs
4.7. Hemizona binding assay
4.8. Antisperm antibody assays
4.9. In vitro fertilization (IVF), Intracytoplasmic sperm injection (ICSI)
5. Selected clinical male infertility syndromes with impairment of sperm function
5.1. Antisperm antibodies
5.2. Immotile cilia syndrome
5.3. Spinal cord injury/anejaculatory infertility
5.4. Nifedipine-associated Infertility
6. Therapies and future directions
7. References
8. Entire manuscript