[Frontiers in Bioscience 1, e72-77, August 1,1996]
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CAVEAT LECTOR



APPLICATION OF MOLECULAR BIOLOGY-BASED METHODS TO THE DIAGNOSIS OF INFECTIOUS DISEASES

Udo Reischl

Institute of Medical Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany

Received 06/18/96; Accepted 07/19/96; On-line 08/01/96

TABLE OF CONTENTS

1. Abstract
2. Serodiagnosis of viral pathogens is improved by the availability of recombinant antigens.
3. PCR, the all-purpose tool in nucleic acid-based diagnostics.
4. The reliable and rapid diagnosis of tuberculosis is founded on a productive combination of traditional and modern methodologies.
5. Bacterial infection chains can be clarified with the help of DNA fingerprinting techniques.
6. The rapid and culture-independent assessment of antibiotic resistance is still a challenge which might be accessible on genomic level.
7. Future Prospects
8. References
9. Entire manuscript

Key words: HIV, serodiagnosis, PCR, nucleic acid-based diagnostics, mycobacteria, tuberculosis, fingerprinting, antibiotic resistance.