 |
PIG alpha1,3GALACTOSYLTRANSFERASE: A MAJOR TARGET FOR GENETIC MANIPULATION IN XENOTRANSPLANTATION
Karen Strahan, Andrew Preece and Kenth Gustafsson
Division of Cell & Molecular Biology, Institute of Child Health, University of London, 30 Guilford St., London WC1N 1EH, UK
Received 06/21/96; Accepted 07/02/96; On-line 07/08/96
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Gala1,3Gal: the major target for human anti-pig NAb
- 4. Evolution and possible function of the Gala1,3Gal epitope
- 4.1. Evolution of the gene encoding the a1,3GT
- 4.2. The possible functional significance of the Gala1,3Gal epitope
- 5. Down-regulation or obliteration of the Gala1,3Gal epitope
- 5.1. Knock-out of the gene encoding a1,3GT
- 5.2. a1,2FT competition with the substrate for a1,3GT
- 5.3. Oligonucleotide antisense inhibition of a1,3GT expression
- 5.4. Ribozymes as tools for down-regulation of the a1,3GT expression
- 6. Concluding remarks
- 7. Acknowledgments
- 8. References
- 9. Entire manuscript
Key Words: Xenotransplantation, Endothelial cell, a1,3galactosyltransferase,
Natural Antibodies, Gene knock-out, Antisense, Ribozyme
Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.
|
