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THE CARBOXY-TERMINAL DOMAIN OF HUMAN SURFACTANT PROTEIN B IS NOT REQUIRED FOR SECRETION IN MILK OF TRANSGENIC MICE
Sinai Yarus1, Timothy E. Weaver2, and Jeffrey M. Rosen1
1 Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3498, USA
2 Division of Neonatology and Pulmonary Biology, University of Cincinnati College of Medicine and Children's Hospital Medical Center, Cincinnati, Ohio 45267-0541, USA
Received 3/24/97; Accepted 4/22/97; On-line 5/1/97
7. REFERENCES
1. S. Yarus, N.M. Greenberg, Y. Wei, J.A. Whitsett, T.E. Weaver & J.M. Rosen: Secretion of unprocessed human surfactant protein B in milk of transgenic mice. Transgenic Res, 6, 51-58 (1997)
2. S. Lin, K.S. Phillips, M.R. Wilder & T.E. Weaver: Structural Requirements for Intracellular Transport of Pulmonary Surfactant Protein B (SP-B). Biochimica et Biophysica Acta, 1312, 177-185 (1996)
3. S. Yarus and D. L. Hadsell "The Mammary Transgene Database" Sinai Yarus (Editor). The Molecular Biology Computational Resource, Baylor College of Med., Houston, TX USA
[http://mbcr.bcm.tmc.edu:80/BEP/ERMB/mtdb.html] (1995)
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Yarus, D. Hadsell & J.M. Rosen: Engineering transgenes for use in the mammary gland. In: Genetic Engineering: Principles and Methods. Eds. Setlow J, Plenum Publishing, NY (1996)
5. W.S. Bawden, R.J. Passey & A.G. MacKinlay: The genes encoding the major milk-specific proteins and their use in transgenic studies and protein engineering. In: Biotechnology and Genetic Engineering Reviews. Eds. Tombs MP, Intercept Ltd., Andover, Hampshire, U.K. (1994)
6. E.M. Bayna & J.M. Rosen: Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice. Nucl Acids Res, 18, 2977-2985 (1990)
7. T.C. Dale, M.J. Krnacik, C. Schmidhauser, C.L. Yang, M.J. Bissell & J.M. Rosen: High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region. Mol Cell Biol, 12, 905-914 (1992)
8. D.L. Hadsell, N.M. Greenberg, J.M. Fligger, C.R. Baumrucker & J.M. Rosen: Targeted expression of des(1-3)human insulin-like growth factor I(IGF-I) in transgenic mice influences mammary gland development and IGF-binding protein expression. Endocrinology, 137, 321-330 (1996)
9. Y. Wei, S. Yarus, N.M. Greenberg, J. Whitsett & J.M. Rosen: Production of human surfactant protein C in milk of transgenic mice. Transg Res, 4, 232-240 (1995)
10. J. Sambrook, E.F. Fritsch & T. Maniatis: Molecular Cloning: A Laboratory Manual. Eds. Nolan C, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989)
11. K.F. Lee, F.J. DeMayo, S.H. Atiee & J.M. Rosen: Tissue-specific expression of the rat beta-casein gene in transgenic mice. Nucleic Acids Res, 16, 1027-1041 (1988)
12. J.C. Clark, T.E. Weaver, H.S. Iwamoto, M. Ikegami, A.H. Jobe, W.M. Hull & J.A. Whitsett: Decreased lung compliance and air trapping in heterozygous SP-B deficient mice. Am J Respir Cell Mol Biol, 16, 46-52 (1997)
13. N.M. Greenberg, J.W. Anderson, A.J. Hsueh, K. Nishimori, J.J. Reeves, D.M. deAvila, D.N. Ward & J.M. Rosen: Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice. Proc Natl Acad Sci U S A, 88, 8327-8331 (1991)
14. H. Schagger & G. vonJagow: Tricine sodium-dodecyl sulfate-polyacrylamide gel electrophoresis. Analyt Biochem, 166, 368-379 (1987)
15. H.T. Akinbi, J.S. Breslin, M. Ikegami, H.S. Iwamoto, J.C. Clark, J.A. Whitsett, A.H. Jobe & T.E. Weaver: Rescue of SP-B knockout mice with a truncated SP-B proprotein: Function of the C-terminal propeptide. J Biol Chem, 272 (15):9640-9647 (1997)
16. P. Bornstein & G. Balian: Cleavage at Asn-Gly bonds with hydroxylamine. Methods Enzymol, 47, 132-145 (1977)
17. S. Lin, H.T. Akinbi, J.S. Breslin & T.E. Weaver: Structural Requirements for Targetting of Surfactant Protein B (SP-B) to Secretory Granules in vitro and in vivo. J Biol Chem, 271, 19689-19695 (1996)
18. T. Burdon, R.J. Wall, A. Shamay, G.H. Smith & L. Hennighausen: Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype. Mech Dev, 36, 67-74 (1991)
19. A. Shamay, V.G. Pursel, E. Wilkinson, R.J. Wall & L. Hennighausen: Expression of the whey acidic protein in transgenic pigs impairs mammary development. Transgenic Res, 1, 124-132 (1992)
20. C. Jhappan, A.G. Geiser, E.C. Kordon, D. Bagheri, L. Hennighausen, A.B. Roberts, G.H. Smith & G. Merlino: Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation. EMBO J, 12, 1835-1845 (1993)
21. E.C. Kordon, R.A. McKnight, C. Jhappan, L. Hennighausen, G. Merlino & G.H. Smith: Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population. Dev Biol, 168, 47-61 (1995)
22. B. Li, N. Greenberg, L.C. Stephens, R. Meyn, D. Medina & J.M. Rosen: Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development. Cell Growth Differ, 5, 711-721 (1994)
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