[Frontiers in Bioscience 2, a37-45, November 1, 1997]
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CAVEAT LECTOR




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A p53 GROWTH ARREST PROTECTS FIBROBLASTS FROM ANTICANCER AGENTS

E. Siobhan McCormack, Arthur M. Bruskin, Gary V. Borzillo

OSI Pharmaceuticals Inc., 106 Charles Lindbergh Blvd., Uniondale, NY 11553-3649

Received 10/27/97 Accepted October 31, 1997

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Materials and Methods
3.1 Cell lines 3.2 Protein analyses 3.3 Chemoprotection colony assays
4. Results
4.1 Protection from taxol 4.2 Protection from vinblastine, etoposide and Ara-C 4.3 p53 enhances survival weakly for cells treated with 5-FU, and does not protect from cisplatin
5. Discussion
6. Acknowledgment
7. References
8. Entire manuscript

Key words: p53, Chemoprotection, Cell cycle, G1 phase, Chemotherapy