[Frontiers in Bioscience 1, d1-11 January 1, 1997]
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Versions: 1997, 2000

IMMUNE REGULATION BY CD40-CD40-L INTERACTIONS

Cees van Kooten and Jacques Banchereau

Dept of Nephrology, Leiden University Hospital, Leiden, the Netherlands and Schering-Plough, Laboratory for Immunological Research, Dardilly, France

Received 11/14/96; Accepted 12/02/96; On-line 01/01/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Immune regulation by CD40-CD40-L interactions
3.1. Structure and expression of CD40 and its ligand
3.2. CD40 signal transduction
3.3. Functions of CD40 in vitro
3.3.1. B lymphocytes
3.3.2. Monocytes and dendritic cells
3.3.3. Non-hematopoietic cells
3.4. In vivo functions of CD40/CD40-L interactions
3.4.1. Hyper-IgM syndrome
3.4.2. Formation of germinal centers
3.4.3. CD40/CD40-L: treatment of autoimmunity
3.4.4. CD40/CD40-L: induction of transplantation tolerance
4. Concluding remarks
5. References
6. Entire manuscript

Keywords: Basic science review, Immunology, CD40, CD40-L