[Frontiers in Bioscience 2, d49-60, February 15, 1997]
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ROLE OF NF-KappaB IN THE CONTROL OF APOPTOTIC AND PROLIFERATIVE RESPONSES IN IL-2-RESPONSIVE T CELLS

Javier Gómez, David García-Domingo, Carlos Martínez-A.1 and Angelita Rebollo

Department of Immunology and Oncology, Centro Nacional de Biotecnología, Campus de Cantoblanco, E-28049 Madrid, Spain

Received 1/21/97; Accepted 1/30/97; On-line 2/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. NF-kappaB controls IL-2 gene expression
4. NF-kappaB and the IL-2 receptor
5. NF-kappaB and apoptosis
6. A dual role for NF-kappaB gene family members in programmed cell death
7. Role of NF-kappaB in IL-2-triggered T cell responses
8. Concluding remarks
9. References
10. Entire manuscript

Key words: NF-kappaB, Transcription factors, Apoptosis, IL-2, IL-2 receptor