[Frontiers in Bioscience 2, d173-188, May 1, 1997]
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IMMUNE RESPONSE OF NEONATES ELICITED BY SOMATIC TRANSGENE VACCINATION WITH NAKED DNA

Adrian Bot, Stefan Antohi and Constantin Bona

The Department of Microbiology, Mount Sinai Medical School, New York, USA

Received 4/8/97; Accepted 4/15/97; On-line 5/1/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Immune responsiveness of the neonatal B cells
3.1. Humoral responses of mice immunized as neonates with naked DNA
4. Immune responsiveness of the neonatal T cells
4.1. Quantitative differences between the immune systems of neonates and adults
4.2. Functional differences between the lymphocytes of neonates and adults
4.3. Cellular immune responses of mice immunized as newborns with naked DNA
5. Towards the development of a new generation of efficient vaccines for infants
6. Acknowledgments
7. References
8. Entire manuscript

Key words: newborn, naked DNA, vaccine, influenza virus