[Frontiers in Bioscience 2, d271-282, June 1, 1997]
Reprints
PubMed
CAVEAT LECTOR



Table of Conents
 Previous Section   Next Section

THE ROLE OF LANGERHANS ISLETS IN PANCREATIC DUCTAL ADENOCARCINOMA
Parviz M. Pour

The UNMC/Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE

Received 5/6/97 Accepted 6/2/97

14. REFERENCES

1. Boring CC, Squires TS, Tong T, Montgomery S: Cancer statistics, 1994. CA Cancer J Clin 44, 7­26, (1994)


2. Murr MM, Sarr MG, Oishi AJ, van Heerden JA: Pancreatic cancer. CA, 44, 304-318 (1994)


3. Cubilla AL, Fortner J, Fitzgerald PJ: Lymph node involvement in carcinoma of the head of the pancreas area. Cancer 41, 880­887, (1978)


4. Best EW, Walker CB, Baker PM, Delaquis FM, McGregor JT, McKenzie AC: Summary of a Canadian study of smoking and health. Can Med Assoc J 96, 1104­1108 (1967)


5. Hammond EC: Smoking in relation to the death rates of one million men and women. Natl Cancer Inst Monogr 19, 127­204 (1966)


6. Hirayama T: Smoking in relation to death rates of 265,118 men and women in Japan. Tokyo:Natl Cancer Center Res Inst, p. 14 (1967)


7. Maruchi N, Brian D, Ludwig J, Elveback LR, Kurland LT: Cancer of the pancreas in Olmsted County, Minnesota, 1935­1974. Mayo Clin Proc 54, 245­249 (1979)


8. Moossa AR, Levin B: Collaborative studies in the diagnosis of pancreatic cancer. Semin Oncol 6, 298­308 (1979)


9. Wood RA, Schwarz SS, Rubenstein AH, Moossa AR: A prospective evaluation of glucose intolerance in patients suspected of having pancreatic cancer. Br J Surg 65, 815 (1978)


10. Kessler II: Cancer mortality among diabetics. J Natl Cancer Inst 44, 673-686 (1970)


11. Birt DF, Salmasi S, Pour PM: Enhancement of experimental pancreatic cancer in Syrian golden hamsters by dietary fat. J Natl Cancer Inst 67, 1327­1332 (1981)


12. Eustis SL, Boorman GA: Proliferative lesions of the exocrine pancreas: relationship to corn oil gavage in the National Toxicology Program. J Natl Cancer Inst 75, 1067­1073 (1985)


13. Haseman JK, Huff JE, Rao GN, Arnold JE, Boorman GA, McConnell EE: Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/6N X C3H/HeN)F1 (B6C3F1) mice. J Natl Cancer Inst 75, 975­984 (1985)


14. Longnecker DS, Roebuck BD, Kuhlmann ET: Enhancement of pancreatic carcinogenesis by a dietary unsaturated fat in rats treated with saline or N­nitroso(2­hydroxypropyl)(2­oxopropyl)amine. J Natl Cancer Inst 74, 219­222 (1985)


15. Roebuck BD, Yager JD Jr, Longnecker DS, Wilpone SA: Promotion by unsaturated fat of azaserine­induced pancreatic carcinogenesis in the rat. Cancer Res 41, 3961­3966 (1981)


16. Woutersen RA; van Garderen­Hoetmer A, Bax J, Scherer E: Modulation of dietary fat­promoted pancreatic carcinogenesis in rats and hamsters by chronic ethanol ingestion. Carcinogenesis 10, 453­459 (1989)


17. Simopoulos AP: Nutritional cancer risks derived from energy and fat. Med Oncol Tumor Pharmacother 4, 227-239 (1987)

18. Longnecker DS, Shinozuka H, Dekker A: Focal acinar cell dysplasia in human pancreas. Cancer 45, 534-540 (1980)

19. Bockman DE: Cell of origin of pancreatic cancer. Experimental animal tumors related to human pancreas. Cancer 47, 1528-1534 (1981)

20. Flaks B, Moore MA, Flaks A: Ultrastructure analysis of pancreatic carcinogenesis. V. Changes in differentiation of acinar cells during chronic treatment with N-nitrosobis (2-hydroxylpropyl)amine. Carcinogenesis 3, 485-498 (1982)

21. Longnecker DA, Roebuck BD, Kuhlmann ET, Curphey TJ: Induction of pancreatic carcinomas in rats with N-nitroso(2-hydroxylpropyl)(2-oxopropyl)amine: Histopathology. J Natl Canc Inst 74, 209-217 (1985)

22. Longnecker DS, Curphey TJ: Adenocarcinoma in azaserine-treated rats. Cancer Res 35, 2249-2258 (1975)

23. Reddy JK, Scarpelli DG, Rao MS: Experimental pancreatic carcinogenesis. Proceedings of the 12th International Cancer Congress 99-109 (1979)

24. Bensley RR: Studies on the pancreas of the guinea pig. Am J Anat 12, 297­302 (1911)


25. Henderson JR: Why are there islets of Langerhans? Lancet 2, 469-470 (1969)

26. v. Schönfeld J, Goebell H, Muller MK: The islet­acinar axis of the pancreas. Intl J Pancreatol 16, 131­140 (1994)

27. Kramer MF, Tan HT: The peri­insular acini of the pancreas of the rat. Z Zellforsch 86, 163­170 (1968)

28. Pour PM, Hauser RE: Exocrine secretion of pancreatic hormones: possible mechanisms. Intl J Pancreatol 2, 277­287 (1987)

29. Pour PM, Wilson R: Experimental pancreas tumor. In: Cancer of the Pancreas. Ed: Moossa AR, Williams and Wilkins, Baltimore, London pp. 37­158, (1980)

30. Patent GJ, Alpert M: Histological changes in the pancreatic islets of alloxan­treated mice, with comments on ­cell regeneration. Acta Anat 28, 341-342 (1964)

31. Takahashi M, Pour PM: The results of pancreatography during pancreatic carcinogenesis. Am J Pathol 91, 57­70 (1978)

32. Bouwens L, Wang R­N, De Blay E, Pipeleers DG, Klöppel G : Cytokeratins as markers of ductal cell differentiation and islet neogenesis in the neonatal rat pancreas. Diabetes 43, 1279-1283 (1994)

33. Klöppel G. Lenzen S: Anatomy and physiology of the endocrine pancreas. In: Pancreatic Pathology. Eds: Klöppel G, Heitz P, Churchill Livingstone, London, New York pp. 133­153, (1984)

34. Pour PM: Experimental pancreatic cancer. Am J Surg Pathol 13 (S1), 96-103 (1989)

35. Pour P, Mohr U, Cardesa A, Althoff J, Kruger FW: Pancreatic neoplasms in an animal model: morphological, biological, and comparative studies. Cancer 36, 379­389 (1975)

36. Pour PM: Induction of unusual pancreatic neoplasms, with morphologic similarity to human tumors, and evidence for their ductal/ductular cell origin. Cancer 55, 2411­2416 (1985)

37. Pour PM, Runge RG, Birt D, Gingell R, Lawson T, Nagel D, Wallcave L, Salmasi SZ: Current knowledge of pancreatic carcinogenesis in the hamster and its relevance to the human disease. Cancer 47, 1573­1589 (1981)

38. Pour PM, Egami H, Takiyama Y: Patterns of growth and metastases of induced pancreatic cancer in relation to the prognosis and its clinical implications. Gastroenterology 100, 529­536 (1991)

39. Egami H, Chaney WG, Takiyama Y, Pour PM: Subcellular localization of blood group A substance produced by pancreatic adenocarcinoma induced in hamsters by N­nitro sobis(2­oxopropyl)amine (BOP) and by its cell line (PC­1) Carcinogenesis 12, 509-514 (1991)

40. Egami H, Takiyama Y, Chaney WG, Cano M, Fujii H, Tomioka T, Metzgar R, Pour PM: Comparative studies on expression of tumor­associated antigens in human and induced pancreatic cancer in Syrian hamsters. Intl J Pancreatol 7, 91­100 (1990)

41. Takiyama Y, Egami H, Pour PM: Expression of human tumor­associated antigens in pancreatic cancer induced in Syrian hamsters. Am J Pathol 136, 707­715 (1990)

42. Fujii HH, Egami H, Chaney W, Pour P, Pelling J: Pancreatic ductal adenocarcinomas induced in Syrian hamsters by N­nitrosobis(2­oxopropyl)amine contain a c­Ki­ras oncogene with a point­mutated codon 12. Molec Carcinogenesis 3, 29S301 (1990) .

43. Mogaki M, Hirota M, Chaney WG, Pour PM: Comparison of p53 protein expression and cellular localization in human and hamster pancreatic cell lines. Carcinogenesis 14, 2589-2594 (1993)

44. Pour PM, Permert J. Mogaki M, Fujii H, Kazakoff K: Endocrine aspects of exocrine cancer of the pancreas . Their patterns and suggested biological significance. Am J Clin Pathol 100, 223­230 (1993)

45. Pour PM, Bell RH: Alteration of pancreatic endocrine cell patterns and their secretion during pancreatic carcinogenesis in the hamster model. Cancer Res 49, 6396- 6400 (1989) .

46. Pour PM: Mechanism of pseudoductular (tubular) formation during pancreatic carcinogenesis in the hamster model. Am J Pathol 130, 335­344 (1988)

47. Pour PM: Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study. Ductular cells, including islet cell precursors, and primary progenitor cells of tumors. Am J Pathol 90, 295-316 (1978) .

48. Pour PM: The endocrine­exocrine pancreas: Its clinical and morphological aspects and hyperplastic and neoplastic patterns. In: Hormone Related Tumors. Eds: Nagasawa H, Abe K, Japan Scientific Societies Press, Tokyo, Springer­Verlag, Berlin pp. 103­120, (1981)

49. Neubert K: Bau und Entwicklung des menschlichen Pankreas. Arch Entwicklungmechn Organ 111,29­118 (1927)

50. Ferner H: Beitrage zur Histobiology der Langerhansschen Inseln des Menschen mit besonderer Berucksichtigung der Silberzellen and ihrer Beziehung zum Pankreas­diabetes. Virchows Arch Pathol Anat 309, 87­136 (1942)

51. Laidlaw GF: Nesidioblastoma, the islet tumor of the pancreas. Am J Pathol 14, 125­134 (l938)

52. Bencosme SA: The histogenesis and cytology of the pancreatic islets in the rabbit. Am J Anat 96, 103­151 (1955)

53. Pour PM: Ductal Adenocarcinoma. In: Atlas of Exocrine Pancreatic Tumors. Morphology, Biology and Diagnosis with an International Guide for Tumor Classification. Eds: Pour PM, Konishi Y, Kloppel G, Longnecker DS, Springer­Verlag, Berlin pp. 117­154, (1994)

54. Pour PM, Donnelly K, Stepan K: Modification of pancreatic carcinogenesis in the hamster model.3. Inhibitory effect of alloxan. Am J Pathol 10, 310-314 (l983)

55. Pour PM, Patil K: Modification of pancreatic carcinogenesis in the hamster model. X. Effect of streptozotocin. J Natl Cancer Inst 71, 1059 1065 (1983)

56. Bell RH Jr, Stayer DS: Streptozotocin prevents develop ment of nitrosamine­induced pancreatic cancer inthe Syrian hamster. J Surg Oncol 24, 258­262 (1983)

57. Bell RH, McCullough PJ, Pour PM: Influence of diabetes on susceptibility to experimental pancreatic cancer. Am J Surg 155, 159-164 (1988)

58. Bell RH, Sayers HJ, Pour PM, Ray MB, McCullough PJ: Importance of diabetes in inhibition of pancreatic cancer by streptozotocin. J Surg Res 46, 515-519 (1989)

59. Pour PM, Kazakoff K, Carlson K: Inhibition of Streptozotocin­induced islet cell tumors and BOP­induced exogenous pancreatic tumors in Syrian hamsters. Cancer Res 50, 1634­1639 (1990)

60. Bell RH, Pour PM: Induction of pancreatic tumors in genetically non­diabetic but not in diabetic Chinese hamsters. Cancer Lett 34, 221­230 (1987)

61. Rosenberg, L, Duguid, WP, Vinik, AI: The effect of cellophane wrapping of the pancreas in the Syrian Golden hamster: autoradiographic observations. Pancreas 4, 31-37 (1989)

62. Rosenberg, L, Duguid, WP, Brown, MA, Vinik, AI: Induction of nesidiablastosis will reverse diabetes in Syrian golden hamster. Diabetes 37, 334-341 (1988)

63. Pour PM, Kazakoff K: Stimulation of islet cell proliferation enhances ductal carcinogenesis in the hamster model. Am J Pathol 149, 1017-1025 (1996)

64. Rosenberg L, Duguid WP, Brown RA: Development of experimental cancer in the head of the pancreas by surgical induction of tissue injury. Am J Surg 147,146-151 (1984)

65. Pour PM, Weide LG, Ueno K, Corra S, Kazakoff K: Submandibular gland as a site for islet transplantation. Intl J Pancreatol 12,187-191 (1992)

66. Ishikawa O, Ohigashi H, Imaoka S, Nakai I, Mitsuo M, Pour PM: The role of pancreatic islets in experimental pancreatic carcinogenicity. Am J Pathol 147, 1456-1464 (1995)

67. Pour PM, Weide L, Liu G, Katherine Kazakoff K, Scheetz M, Toshkov, Ikematsu I, Fienhold MA, Sanger W:
Experimental evidence for the origin of ductal type adenocarcinoma from the pancreas. Am J PatholIn press.

68. Takiyama Y, Egami H, Pour PM: Expression of human tumor-associated antigens in pancreatic cancer induced in Syrian hamsters. Am J Pathol 136,707-715 (1990)

69. Ahrén B, Andrén­Sandberg A: Glucose tolerance and insulin secretion in experimental pancreatic cancer in the Syrian hamster. Res Exp Med 193, 21­26 (1993)

70. Adrian TE, Permert J, Westermark GT: Islet hormones in pancreatic cancer. The association between islet amyloid polypeptide levels anddiabetes. Intl J Pancreatol 16, 274 277 (1994)

71. Warren S: The Pathology of Diabetes Mellitus. Lea & Feibigerl, Philadelphia (1938) page 25.

72. Eusebi V, Capella C, Bondi A, Sess F, Vezzadini P, Mancini AM: Endocrine­paracrine cells in pancreatic exocrine carcinomas. Histopathology 5, 599-613 (1981)

73. Frantz VK: Tumors of the pancreas. In: Atlas of Tumor Pathology, 2nd Sec., Fascicles 27 and 28, Armed Forces Institute of Pathology, Washington, DC (1959)

74. Moossa AR, Levin B : Collaborative studies in the diagnosis of pancreatic cancer. Seznin Oncol 6, 298­308 (1979)

75. Wood RA, Schwarz SS, Rubenstein AH, Moossa AR: A prospective evaluation of glucose intolerance in patients suspected of having pancreatic cancer. Intl J Surg 65,815 (1978)

76. Kessler II: Cancermortality among diabetics. J Natl Cancer Inst 44, 673- 686 (1970)

77. Ariyama J: Abnormal glucose tolerance in patients with early pancreatic carcinoma. Intl J Pancreatol 16, 91 (1994)

78. Cersosimo E, Pisters P, Pesola G, McDermott K, Bajorunas D, Brennen MF: Insulin secretion and action in patients with pancreatic cancer. Cancer 67, 46-493 (1991)

79. Gullo L, Pezzili R, Morselli­Labate AM: Diabetes and the risk of pancreatic cancer. Intl J Pancreatol 16, 94­95 (1994)

80. Permert J, Larsson J, Westermark GT, Herrington MK, Christmanson L, Pour PM, Westermark P, Adrian TE: Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. New Engl J Med 330, 313­318 (1994)

81. Permert J, Ihse I, Jorfeldt L, von Schenk H, Arnqvist HJ, Larsson J: Pancreatic cancer is associated with impaired glucose metabolism. Eur J Surg 159, 101­107 (1993)

82. Noy A, Bielezikian JP: Clinical Review 63. Diabetes and pancreatic cancer: clues to the early diagnosis of pancreatic malignancy. J Clin Endocrinol Metab 79, 1223­1231 (1994)

83. Fogar P, Basso D, Panozzo MP, Del Favero G, Briani G, Fabris C, Angeli FD, Meggiato T, Ferrara C, Plebani M: C­peptide patterns in patients with pancreatic cancer. Anticancer Res 13, 2577­2580 (1993)

84. Ishikawa O, Nakamori S, Ohigashi H, Imaoka S: Increased secretion of proinsulin in patients with pancreatic cancer. Intl J Pancreatol 16, 8989 (1994)

85. Adrian TE, Permert J, Westermark GT: Islet hormones in pancreatic cancer. The association between islet amyloid polypeptide levels and diabetes. Intl J Pancreatol 274­277 (1994)

86. Permert J, Ihse I, Jorfeldt L, von Schenck H, Arqvist H, Larsson J: Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer. Br J Surg 80, 1047­1050 (1993)

87. Permert J, Adrian TE, Jacobsson P, Fruin B, Larsson J: Is the peripheral insulin resistance inpancreatic cancer caused by a tumor­associated factor? Am J Surg 165, 61-67 (1993)

88. Del Favero G, Basso D, Fogar P, Panozzo MP, Meggiato T, Ferrara C, Angeli F, Bigato L, Plebani M: Alterations of serum pancreatic hormones in pancreatic cancer patients. Intl J Pancreatol 16, 84­86 (1994)

89. Westermark P, Wernstedt C, Wilander E, Hayden DW, OlBrien TD, Johnson KH: Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a novel polypeptide like protein also present in normal islet cells. Proc Natl Acad Sci USA 84, 3881­3885 (1987)

90. Leighton B, Cooper GJS: Pancreatic amylin and calcitonin gene­related peptide cause resistance to insulin in skeletal muscle in vitro. Nature 335, 632-635 (1988)

91. Vecchia CLl Negri E, Franceschi S, D'Avanzo Bl Boyle P: Diabetes and pancreatic cancer risk. An epidemiological assessment. Int J Pancreatol 16, 81-82 (1994)

92. Larsson J, Permert J: Relationship between pancreatic cancer and diabetes. Intl J Pancreatol 16, 82­84 (1994)

93. Yamao K, Nakazawa S, Fujimoto M, Yamada M, Michgrub S, Albores-Saavedra J: Intraductal papillary mucinous tumor, non-invasive and invasive. In :Atlas of Exocrine Pancreatic Tumors. Morphology, Biology and Diagnosis with an International Guide for Tumor Classification. Eds: Pour PM, Konishi Y, Kloppel G, Longnecker DS, Springer­Verlag, Berlin pp. 43­66, (1994)