|[Frontiers in Bioscience 2, d271-282, June 1, 1997]|
THE ROLE OF LANGERHANS ISLETS IN PANCREATIC DUCTAL ADENOCARCINOMA|
Parviz M. Pour
The UNMC/Eppley Cancer Center, University of Nebraska
Medical Center, Omaha, NE
Received 5/6/97 Accepted 6/2/97
which has a high incidence worldwide, is a disease with poor prognosis
since it evades early detection. In the United States, the disease
presently accounts for 3% of all cancers responsible for 5% of
all cancer deaths (1). It is the fourth most common cause of cancer
death in men (exceeded only by lung, colorectal and prostatic
cancers) and the fifth cause of cancer death in women (exceeded
by breast, colorectal,lung and ovarianuterine cancers).
It is estimated that, in 1997, about 27,000 new cases of pancreatic
cancer will be diagnosed in the United States, and 25,900 people
will die of this disease (1).
Although it is generally believed that cancers of
exocrine pancreas in humans originate from ductal cells, their
derivation from acinar cells has also been considered(18). Experimental
results in different species point to the differences in the cell
of origin of tumors induced in pancreas (19-23). Although rats
primarily develop acinar cell tumors (21-22), ductal and ductular
cells are believed to be the progenitor cells of pancreatic cancer
In this review, the potential sites of origin of pancreatic adenocarcinomas are discussed.