[Frontiers in Bioscience 2, d271-282, June 1, 1997]
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CAVEAT LECTOR



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THE ROLE OF LANGERHANS ISLETS IN PANCREATIC DUCTAL ADENOCARCINOMA
Parviz M. Pour

The UNMC/Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE

Received 5/6/97 Accepted 6/2/97 TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Historical background
4. Interaction of exocrine and endocrine pancreas
5. Patterns of islets during pancreatic carcinogenesis
6 Evidence for the importance of intact islets for pancreatic adenocarcinoma induction
7. Effect of exogenous insulin on pancreatic adenocarcinoma induction
8. Induction of ductal-type adenocarcinoma within islet transplants
9. Association between pancreatic cancer and altered glucose metabolism
10. Alteration of amyloid polypeptide (IAPP) in pancreatic cancer patients
11. Mechanism of altered glucose metabolism in pancreatic adenocarcinoma
12. Perspective
13. Acknowledgment
14.References
15. Entire Manuscript

Keywords: Langerhans islets, Pancreatic ductual adenocarcinoma