[Frontiers in Bioscience 2, d331-342, July 1, 1997]
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SPECIFICITY IN THE cAMP/PKA SIGNALING PATHWAY. DIFFERENTIAL EXPRESSION, REGULATION, AND SUBCELLULAR LOCALIZATION OF SUBUNITS OF PKA.

 Bjørn S. Skålhegg and Kjetil Taskén.

 Institute of Medical Biochemistry, University of Oslo, P.O. Box 1112, N-0317 Oslo, Norway

 Received 6/24/97; Accepted 6/30/97

 TABLE OF CONTENTS

1. Abstract
2. Cyclic AMP and the cAMP-dependent protein kinase (PKA) signaling system
3. Isozymes of PKA
3.1. Multiple isoforms of regulatory and catalytic subunits of PKA
3.2. Features of regulatory and catalytic subunits of PKA
3.2.1. Structure of regulatory subunits
3.2.2. Structure of catalytic subunits
4. Regulation of levels and expression of the regulatory and catalytic subunits
4.1. Developmental expression of regulatory and catalytic subunits
4.2. Hormonal regulation of PKA in rat Sertoli cells
4.3. Mitogen regulation of PKA in lymphoid cells
4.4. Transcriptional regulation of the genes for PKA subunits
5. PKA isozyme composition and characteristics
6. Subcellular localization of PKA
7. Effects of cAMP mediated by specific isozymes of PKA
7.1. Cyclic AMP effects mediated by PKAI
7.2. Cyclic AMP effects mediated by PKAII
8. Summary and perspectives
9.References
10.Entire manuscript

Keywords: cAMP, PKA, molecular biology, biochemistry