[Frontiers in Bioscience 2, d343-352, July 15, 1997]
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HUMAN SKIN BASEMENT MEMBRANE IN HEALTH AND IN AUTOIMMUNE DISEASES

Lawrence S. Chan

Medicine Service, Section of Dermatology, Lakeside Division, VA Chicago Health Care System, and Division of Immunodermatology, Department of Dermatology, Northwestern University Medical School, 300 E. Superior St., Chicago, IL 60611

Received 7/3/97 Accepted 7/10/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Human skin basement membrane structure and function
3.1 Skin basement membrane structure
3.1.1 Hemidesmosome
3.1.2 Lamina lucida
3.1.3 Lamina densa
3.1.4 Sub-lamina densa
3.2 Skin basement membrane function
4. Human skin basement membrane as a target of autoimmune diseases
4.1 Techniques for classification of autoimmune subepidermal blistering diseases
4.1.1 Direct and indirect immunofluorescence studies on chemically separated skin section
4.1.2 Direct and indirect immunoelectron microscopy
4.1.3 Determination of specific target antigens
4.2 Diseases characterized by autoantibodies directed against hemidesmosome
4.2.1 Bullous pemphigoid
4.2.2 Linear IgA bullous dermatosis
4.3 Diseases characterized by autoantibodies directed against lower lamina lucida
4.3.1 Cicatricial pemphigoid with autoantibodies to bullous pemphigoid antigen
4.3.2 Anti-laminin cicatricial pemphigoid
4.3.3 Anti-p105 pemphigoid
4.4 Diseases characterized by autoantibodies directed against sub-lamina densa
4.4.1 Epidermolysis bullosa acquisita
5. Summary
6. Acknowledgments
7. References
8. Entire manuscript

Key words: Skin, Basement membrane, Autoantibody, Laminin, Type VII collagen, Type XVII collagen