[Frontiers in Bioscience 2, d380-386, July 15, 1997]
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LEUKOTRIENE C4 SYNTHASE: A CRITICAL ENZYME FOR THE BIOSYNTHESIS OF SRS-A.

Bing K. Lam

Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115.

Received 7/11/97 Accepted 7/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Biochemical Properties of Native LTC4 Synthase
4. LTC4 Synthase cDNA
5. Biochemical Properties of Recombinant LTC4 Synthase
6. Catalytic Mechanism of Conjugation
7. Genomic Organization of Human LTC4 Synthase Gene
8. Chromosomal Localization of Human LTC4 Synthase Gene
9. Perspective
10. Acknowledgments
11. References
12. Entire manurscript

Keywords: Catalytic mechanism, Asthma, cDNA, Gene