[Frontiers in Bioscience 2, d401-416, August 15, 1997]
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NATURAL IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUSES: PROSPECTS FOR AIDS VACCINES

Omar Bagasra and Muhammad Amjad

The Dorrance H. Hamilton Laboratories, Section of Molecular Retrovirology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical Collage, Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Suite 329, Philadelphia, PA 19107

Received 6/18/97, Accepted 7/22/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. The retroviruses and their ability to integrate into the host genome
4. What immune mechanisms are responsible for inhibiting retroviral replication: a new hypothesis
5. Scientific basis for current vaccines
5.1. Development of vaccine based on humoral immunity
5.2. Development of vaccine based on cell-mediated immunity
6. Anomalous observations with retroviral infections: is there "molecular immunity"?
6.1. Epidemiological studies
7. Other evidence for " molecular immunity": no manifestation of disease with other lentiviral infection
8. "Molecular immunity" needed to be explained
9. Role of CD8+ cell in the development of anti-retroviral immunity
10. Are beta-chemokines the answer for CD8+ cell factors?
11. Some cofactors can compromise Immunity
12. Factors which interfere in the anti-retroviral "molecular immunity" pathways
13. Two outcome scenarios
14. The twelve steps of molecular immunity
15. Acknowledgments
16. References
17. Entire manuscript
Keywords: HIV-1, AIDS, Retrovirus, Vaccine, CD8+, Lymphocyte, Chemokines, Molecular immunity