<[Frontiers in Bioscience 2, d427-437, September 15, 1997]

[Frontiers in Bioscience 2, d427-437, September 15, 1997]
Reprints
PubMed
CAVEAT LECTOR




Table of Conents
 Previous Section   Next Section

MULTIPLE TRANSPORT PROTEINS INVOLVED IN THE DETOXIFICATION OF ENDO- AND XENOBIOTICS

Yogesh C. Awasthi1,2, Sanjay Awasthi3, and Piotr Zimniak4

Departments of 2Human Biological Chemistry & Genetics and 3Internal Medicine, University of Texas Medical Branch, Galveston, Texas; and 4Department of Internal Medicine and Biochemistry & Molecular Biology, University of Arkansas for Medical Sciences, and McClellan VA Hospital, Little Rock, Arkansas

Received 9/3/97 Accepted 9/8/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Transport and detoxication mechanisms
3.1. Transport and Phase III detoxication mechanisms
3.2. Efflux of xenobiotic and drugs from mammalian cells
3.3. Transport of xenobiotics/metabolites by erythrocytes
3.4.. Heterogeneity of GSH-conjugates transporters
3.5. ATP-dependence of GSH-conjugate transporter(s)
3.6. Structural properties of erythrocyte transporters
3.7. Functional relatedness between drug efflux pumps and erythrocyte GSH-conjugate transporter, DNP-SG ATPase
3.8. Transport mechanisms in liver
3.9. Drug efflux pumps; Pgp and MRP
3.10. P-glycoprotein
3.11. Multiple drug resistance associated protein (MRP)
3.12. Does MRP transport only anionic conjugates?
3.13. MRP and DNP-SG ATPase
3.14. Multi-specific organic anion transporter (MOAT)
4. Future directions
5. Acknowledgment
6. References
7. Entire manuscript

Key words: Glutathione conjugates, Dinitrophenyl S-glutathione ATPase, P-glycoprotein, Multidrug resistance associated protein, Drug resistance, Drug Transport