[Frontiers in Bioscience 2, d3438-448, September 15, 1997]
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CAVEAT LECTOR




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The DCC Protein -- NEURAL DEVELOPMENT AND THE MALIGNANT PROCESS

Kimberly M. Rieger-Christ, Karina L. Brierley and Michael A. Reale

Department of Internal Medicine/Oncology, Yale School of Medicine/West Haven Veterans Administration Medical Center, 333 Cedar St., P.O. Box 208032, New Haven, CT 06520-8032

Received 8/25/97 Accepted 9/5/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. DCC and Development
3.1. DCC guides axonal migrations
3.2 DCC guides cell migrations
3.3. Summary
4. DCC and Cancer
4.1. 18q Allelic loss and DCC expression studies
4.2. Experimental approaches
4.3. Summary
5. Perspective
6. Acknowledgments
7. References
8. Entire manuscript

Key words:DCC (deleted in colorectal cancer), NCAM (neural cell adhesion molecule) , Netrins, Tumor suppressor, unc-40, Frazzled