[Frontiers in Bioscience 2, d619-634, December 15, 1997]
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HUMAN IMMUNODEFICIENCY VIRUS TYPE I AS A TARGET FOR GENE THERAPY

Magnús Gottfredsson and Paul R. Bohjanen

Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710

Received 11/17/97 Accepted 11/24/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. HIV-1 life cycle
4. Viral targets for gene therapy
4.1. Tat and TAR
4.2. Rev and RRE
4.3. Nef
4.4. The
pol gene
4.4.1. Reverse transcriptase
4.4.2. Integrase
4.4.3. Protease
4.5. The
gag gene
4.6. The
env gene
4.7. Vpr
4.8. The 5' leader sequence
4.9. Packaging sequence y
4.10. HIV-regulated suicide genes
5. Combinations of antiviral strategies
5.1. Ribozymes and RNA decoys
5.2.
Trans-dominant mutant combinations
5.3. Multitarget ribozymes
5.4. Other combinations

6. Perspective
7. Acknowledgments
8. References
9. Entire manuscript

Key words: HIV-1, AIDS, Gene therapy, Tat, TAR, Rev, PRE, Nef, Vpr, Reverse transcriptase, Integrase, Protease, RNA decoys, Ribozymes, Trans-dominant mutants