[Frontiers in Bioscience 2, e21-27, 1997]
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WEEKLY PACLITAXEL AS A RADIATION SENSITIZER FOR LOCALLY ADVANCED GASTRIC AND PANCREATIC CANCERS:THE BROWN UNIVERSITY ONCOLOGY GROUP EXPERIENCE

William M. Sikov, MD and Howard Safran, MD

Department of Medicine, The Miriam Hospital and the Brown University School of Medicine, Providence, RI

Received 3/24/97 Accepted 4/3/97; On-line 5/1/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. Background
2.2. Paclitaxel
2.3. Paclitaxel, radiation and the cell cycle
2.4. Paclitaxel as a radiation sensitizer in NSCLC
2.5. Paclitaxel/RT is unaffected by p53 mutations in NSCLC
3. Phase I study of paclitaxel/RT for gastric and pancreatic cancer
4. Phase II studies of neoadjuvant paclitaxel/RT in locally advanced gastric and pancreatic cancers
4.1. Preliminary results
4.2. Activity of paclitaxel/RT in pancreatic and gastric tumors with p53 mutations
5. Future directions
6. Acknowledgment
7. References
8. Entire manuscript