[Frontiers in Bioscience 2, c30-39, December 15, 1997]

	[Frontiers in Bioscience 2, c30-39, December 15, 1997] Reprints PubMed CAVEAT LECTOR
	*THE IN OVO* CARCINOGENEICITY ASSAY (IOCA): A REVIEW OF AN EXPERIMENTAL APPROACH FOR RESEARCH ON CARCINOGENESIS AND CARCINOGENICITY TESTING Harald Enzmann¹ and Klaus D. Brunnemann²** 1Bayer AG, Institute of Toxicology, 42096 Wuppertal, Germany and ²American Health Foundation, Valhalla, NY 10595, USA Received 7/21/97 Accepted 11/14/97 TABLE OF CONTENTS 1. Abstract 2. Introduction: avian models of carcinogenicity 3. Carcinogen-induced cellular changes in embryonic avian liver 3.1 Induction of adenoid formations by carcinogens 3.2 Carcinogen-induced hepatocellular nuclear enlargement 3.3 Quantification of carcinogen-induced nuclear enlargement 3.4 Significance of the carcinogen-induced nuclear enlargement 4. Carcinogen induced focal hepatic lesions in the in ovo carcinogenicity assay (IOCA) 4.1 Induction of focal hepatic lesions in avian embryonic liver 4.2 Experimental induction of focal hepatic lesions in rodents 4.3 Focal hepatic lesions as end points in carcinogenicity testing 5. Focal hepatic lesions as endpoints in carcinogenicity testing Induction of damage to mitochondrial DNA in ovo 5.1 Mitochondrial DNA as target for genotoxic chemicals 5.2 Studies of mitochondrial DNA in carcinogen-exposed embryonic turkey liver 6. Perspectives of the IOCA 7. Acknowledgements 8. References 9. Entire manuscript Key words: Carcinogenicity, toxicology, non-animal method, carcinogenesis, preneoplasia, liver, mitochondrial DNA, short-term-test Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, c30-39, December 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

THE IN OVO CARCINOGENEICITY ASSAY (IOCA): A REVIEW OF AN EXPERIMENTAL APPROACH FOR RESEARCH ON CARCINOGENESIS AND CARCINOGENICITY TESTING

Harald Enzmann¹ and Klaus D. Brunnemann²

1Bayer AG, Institute of Toxicology, 42096 Wuppertal, Germany and ²American Health Foundation, Valhalla, NY 10595, USA

Received 7/21/97 Accepted 11/14/97

TABLE OF CONTENTS

1. Abstract
2. Introduction: avian models of carcinogenicity
3. Carcinogen-induced cellular changes in embryonic avian liver: 3.1 Induction of adenoid formations by carcinogens
3.2 Carcinogen-induced hepatocellular nuclear enlargement
3.3 Quantification of carcinogen-induced nuclear enlargement
3.4 Significance of the carcinogen-induced nuclear enlargement
4. Carcinogen induced focal hepatic lesions in the in ovo carcinogenicity assay (IOCA): 4.1 Induction of focal hepatic lesions in avian embryonic liver
4.2 Experimental induction of focal hepatic lesions in rodents
4.3 Focal hepatic lesions as end points in carcinogenicity testing
5. Focal hepatic lesions as endpoints in carcinogenicity testing Induction of damage to mitochondrial DNA in ovo: 5.1 Mitochondrial DNA as target for genotoxic chemicals
5.2 Studies of mitochondrial DNA in carcinogen-exposed embryonic turkey liver
6. Perspectives of the IOCA
7. Acknowledgements 8. References
9. Entire manuscript

Key words: Carcinogenicity, toxicology, non-animal method, carcinogenesis, preneoplasia, liver, mitochondrial DNA, short-term-test

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.