[Frontiers in Bioscience 2, d78-87, February 15, 1997]
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MAST CELLS AS MODULATORS OF HOST DEFENSE IN THE LUNG

Soman N. Abraham, Krishnan Thankavel and Ravi Malaviya

Departments of Pathology and Molecular Microbiology, Washington University School of Medicine, St. Louis. MO 63110.

Received 2/5/97; Accepted 2/12/97; On-line 2/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Mast cells as immune modulators
3.1 Mast cell heterogeneity
3.2 Mast cell recognition of bacteria
3.3 Mast cell mediator release following bacterial stimulation
3.4 Mast cell phagocytosis and killing of adherent bacteria
3.5 Impaired pulmonary clearance of bacteria in mast cell deficient mice
3.6 Contribution of mast cells to the pathophysiology of bacterial infections
4. Conclusion
5. Acknowledgments
6. References
7. Entire manuscript

Key words: Mast cells, Bacteria, Inflammation, Immunity, Infectious diseases

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