[Frontiers in Bioscience 2, d401-416, August 15, 1997]

	[Frontiers in Bioscience 2, d401-416, August 15, 1997] Reprints PubMed CAVEAT LECTOR
	NATURAL IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUSES: PROSPECTS FOR AIDS VACCINES Omar Bagasra and Muhammad Amjad The Dorrance H. Hamilton Laboratories, Section of Molecular Retrovirology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical Collage, Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Suite 329, Philadelphia, PA 19107 Received 6/18/97, Accepted 7/22/97 9. ROLE OF CD8+ CELL IN THE DEVELOPMENT OF ANTI-RETROVIRAL IMMUNITY The pivotal role of CD8+ T-cells in the development of the anti-retroviral-specific-natural defenses have been well documented (17-24). Briefly, CD8+ T-cells or factors from CD8+ T-cells (CAF) from healthy HIV-1-infected or uninfected individuals can suppress HIV-1 replication without killing the infected cells (10-12, 17-24, 111-115). These are non-CTL, noncytolytic CD8+ cells, characterized by their ability to reduce HIV-1 p24 antigen levels and RT levels in the culture fluids of PBMCs infected with all strains of HIV-1 & 2, SIVs and FIV (10-12, 111-115). This anti-retroviral activity does not appear to be restricted by MHC, or require contact between target and effector cells, occurs at low CD8+ /CD4+ ratios and is oligoclonal in nature (111). The nature of its anti-retroviral activity is via soluble messenger agents, which are unrelated to any known cytokines or chemokines, though currently, this conclusion is controversial (17-24, 116) The exact mechanisms of these antiviral effects are unclear. However, recently, several experimental evidence have been reported which show CAF exert their anti-HIV-1 effects by specifically interrupting HIV-1 transcription (19, 116).

[Frontiers in Bioscience 2, d401-416, August 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

NATURAL IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUSES: PROSPECTS FOR AIDS VACCINES
Omar Bagasra and Muhammad Amjad
The Dorrance H. Hamilton Laboratories, Section of Molecular Retrovirology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical Collage, Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Suite 329, Philadelphia, PA 19107

Received 6/18/97, Accepted 7/22/97

9. ROLE OF CD8+ CELL IN THE DEVELOPMENT OF ANTI-RETROVIRAL IMMUNITY

The pivotal role of CD8+ T-cells in the development of the anti-retroviral-specific-natural defenses have been well documented (17-24). Briefly, CD8+ T-cells or factors from CD8+ T-cells (CAF) from healthy HIV-1-infected or uninfected individuals can suppress HIV-1 replication without killing the infected cells (10-12, 17-24, 111-115). These are non-CTL, noncytolytic CD8+ cells, characterized by their ability to reduce HIV-1 p24 antigen levels and RT levels in the culture fluids of PBMCs infected with all strains of HIV-1 & 2, SIVs and FIV (10-12, 111-115). This anti-retroviral activity does not appear to be restricted by MHC, or require contact between target and effector cells, occurs at low CD8+ /CD4+ ratios and is oligoclonal in nature (111). The nature of its anti-retroviral activity is via soluble messenger agents, which are unrelated to any known cytokines or chemokines, though currently, this conclusion is controversial (17-24, 116) The exact mechanisms of these antiviral effects are unclear. However, recently, several experimental evidence have been reported which show CAF exert their anti-HIV-1 effects by specifically interrupting HIV-1 transcription (19, 116).