[Frontiers in Bioscience 2, d401-416, August 15, 1997]

	[Frontiers in Bioscience 2, d401-416, August 15, 1997] Reprints PubMed CAVEAT LECTOR
	NATURAL IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUSES: PROSPECTS FOR AIDS VACCINES Omar Bagasra and Muhammad Amjad The Dorrance H. Hamilton Laboratories, Section of Molecular Retrovirology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical Collage, Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Suite 329, Philadelphia, PA 19107 Received 6/18/97, Accepted 7/22/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. The retroviruses and their ability to integrate into the host genome 4. What immune mechanisms are responsible for inhibiting retroviral replication: a new hypothesis 5. Scientific basis for current vaccines 5.1. Development of vaccine based on humoral immunity 5.2. Development of vaccine based on cell-mediated immunity 6. Anomalous observations with retroviral infections: is there "molecular immunity"? 6.1. Epidemiological studies 7. Other evidence for " molecular immunity": no manifestation of disease with other lentiviral infection 8. "Molecular immunity" needed to be explained 9. Role of CD8+ cell in the development of anti-retroviral immunity 10. Are beta-chemokines the answer for CD8+ cell factors? 11. Some cofactors can compromise Immunity 12. Factors which interfere in the anti-retroviral "molecular immunity" pathways 13. Two outcome scenarios 14. The twelve steps of molecular immunity 15. Acknowledgments 16. References 17. Entire manuscript Keywords: HIV-1, AIDS, Retrovirus, Vaccine, CD8⁺, Lymphocyte, Chemokines, Molecular immunity Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d401-416, August 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

NATURAL IMMUNITY AGAINST HUMAN IMMUNODEFICIENCY VIRUSES: PROSPECTS FOR AIDS VACCINES
Omar Bagasra and Muhammad Amjad
The Dorrance H. Hamilton Laboratories, Section of Molecular Retrovirology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical Collage, Thomas Jefferson University, Jefferson Alumni Hall, 1020 Locust Street, Suite 329, Philadelphia, PA 19107

Received 6/18/97, Accepted 7/22/97

TABLE OF CONTENTS

2. Introduction
3. The retroviruses and their ability to integrate into the host genome
4. What immune mechanisms are responsible for inhibiting retroviral replication: a new hypothesis
5. Scientific basis for current vaccines: 5.1. Development of vaccine based on humoral immunity; 5.2. Development of vaccine based on cell-mediated immunity
6. Anomalous observations with retroviral infections: is there "molecular immunity"?: 6.1. Epidemiological studies
7. Other evidence for " molecular immunity": no manifestation of disease with other lentiviral infection
8. "Molecular immunity" needed to be explained
9. Role of CD8+ cell in the development of anti-retroviral immunity
10. Are beta-chemokines the answer for CD8+ cell factors?
11. Some cofactors can compromise Immunity
12. Factors which interfere in the anti-retroviral "molecular immunity" pathways
13. Two outcome scenarios
14. The twelve steps of molecular immunity
15. Acknowledgments
16. References 17. Entire manuscript

Keywords: HIV-1, AIDS, Retrovirus, Vaccine, CD8⁺, Lymphocyte, Chemokines, Molecular immunity

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.