[Frontiers in Bioscience 2, d387-400, August 15, 1997]
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CAVEAT LECTOR




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PROCESSING OF MYCOBACTERIAL LIPIDS AND EFFECTS ON HOST RESPONSIVENESS

William W. Barrow

Mycobacteriology Research Unit; Southern Research Unit; Birmingham, Alabama

Received 8/5/97 Accepted 8/12/97

TABLE OF CONTENTS


1. Abstract
2. Introduction
3. Discussion
3.1. Mycobacterial lipids
3.1.1.Mycobacterial cell envelope
3.1.2.Lipids having biological activities
3.1.3. Separation of extractable M. avium lipids by HPLC
3.1.4.Biological activities of HPLC fractions
3.2. Host response to M. avium
3.2.1.Initial interaction
3.2.2.Later stages
3.2.3.Cytokines important in host response
3.3. Postphagocytic events and processing of mycobacterial lipids
3.3.1.Summary and model of phagocytic events
3.3.2.Development of electron-transparent zone
3.3.3.Persistence of lipids in macrophages
3.4. Model for lipid interactions with host cells
3.5. Progression of AIDS and M. avium's contribution to the exacerbation of HIV pathogenesis
3.5.1.HIV pathogenesis
3.5.2.Contribution of M. avium to progression of AIDS
4.Perspective and Summary
5. Acknowledgments
6.References
7. Entire manuscript

Keywords: Mycobacterium avium, Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium, Pathogenesis, Peptidoglycolipid, Glycolipid, Lipopeptide, Lipid, Membrane interactions, Macrophage, Lymphocyte, Cytokine, Eicosanoid, HIV, AIDS