[Frontiers in Bioscience 2, d501-518, October 15, 1997]

	[Frontiers in Bioscience 2, d501-518, October 15, 1997] Reprints PubMed CAVEAT LECTOR
	ROLE OF c-Src TYROSINE KINASE IN EGF-INDUCED MITOGENESIS Allison P. Belsches, Michelle D. Haskell, and Sarah J. Parsons Department of Microbiology and Cancer Center, Box 441, Health Sciences Center, University of Virginia, Charlottesville, VA 22908 Received 10/7/97 Accepted 10/14/97 TABLE OF CONTENTS 1. Abstract 2. Interaction of c-Src with polypeptide growth factor receptors 2.1 Platelet-derived growth factor receptor 2.2 Colony stimulating factor receptor 2.3 Fibroblast growth factor receptor 2.4 Epidermal growth factor receptor and family members 2.4.1 Requirement for c-Src in EGF-induced mitogenesis 2.4.2 Involvement of EGF receptor family members and c-Src in the etiology of human breast cancer 2.4.3 c-Src and HER2 (erbB2/neu) receptor 3. Effect of c-Src on immediate-early events following EGF stimulation of C3H10T cells 3.1 Small molecule second messengers 3.2 Tyrosine phosphorylation of cellular proteins 3.3 EGF receptor-specific and c-Src-specific substrates 3.4 Receptor internalization 4. c-Src and the cytoskeleton 4.1 Focal adhesion kinase 4.2 p130CAS 4.3 p190RhoGAP 4.4 Cortactin (p80/85) 4.5 Sam68 5. Acknowledgments 6. References 7. Entire manuscript Key words: c-Src tyrosine kinase; EGF/EGF receptor, Mitogenesis, Tumorigenesis, c-Src substrates, c-Src binding proteins, C3H10T½ murine fibroblasts Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d501-518, October 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

ROLE OF c-Src TYROSINE KINASE IN EGF-INDUCED MITOGENESIS

Allison P. Belsches, Michelle D. Haskell, and Sarah J. Parsons

Department of Microbiology and Cancer Center, Box 441, Health Sciences Center, University of Virginia, Charlottesville, VA 22908

Received 10/7/97 Accepted 10/14/97

TABLE OF CONTENTS

1. Abstract
2. Interaction of c-Src with polypeptide growth factor receptors: 2.1 Platelet-derived growth factor receptor; 2.2 Colony stimulating factor receptor; 2.3 Fibroblast growth factor receptor; 2.4 Epidermal growth factor receptor and family members

2.4.1 Requirement for c-Src in EGF-induced mitogenesis
2.4.2 Involvement of EGF receptor family members and c-Src in the etiology of human breast cancer
2.4.3 c-Src and HER2 (erbB2/neu) receptor
3. Effect of c-Src on immediate-early events following EGF stimulation of C3H10T cells: 3.1 Small molecule second messengers; 3.2 Tyrosine phosphorylation of cellular proteins; 3.3 EGF receptor-specific and c-Src-specific substrates; 3.4 Receptor internalization
4. c-Src and the cytoskeleton: 4.1 Focal adhesion kinase; 4.2 p130CAS; 4.3 p190RhoGAP; 4.4 Cortactin (p80/85); 4.5 Sam68
5. Acknowledgments
6. References
7. Entire manuscript

Key words: c-Src tyrosine kinase; EGF/EGF receptor, Mitogenesis, Tumorigenesis, c-Src substrates, c-Src binding proteins, C3H10T½ murine fibroblasts

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.