[Frontiers in Bioscience 2, d501-518, October 15, 1997]
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ROLE OF c-Src TYROSINE KINASE IN EGF-INDUCED MITOGENESIS

Allison P. Belsches, Michelle D. Haskell, and Sarah J. Parsons

Department of Microbiology and Cancer Center, Box 441, Health Sciences Center, University of Virginia, Charlottesville, VA 22908

Received 10/7/97 Accepted 10/14/97

TABLE OF CONTENTS

1. Abstract
2. Interaction of c-Src with polypeptide growth factor receptors
2.1 Platelet-derived growth factor receptor
2.2 Colony stimulating factor receptor
2.3 Fibroblast growth factor receptor
2.4 Epidermal growth factor receptor and family members
2.4.1 Requirement for c-Src in EGF-induced mitogenesis
2.4.2 Involvement of EGF receptor family members and c-Src in the etiology of human breast cancer
2.4.3 c-Src and HER2 (erbB2/neu) receptor
3. Effect of c-Src on immediate-early events following EGF stimulation of C3H10T cells
3.1 Small molecule second messengers
3.2 Tyrosine phosphorylation of cellular proteins
3.3 EGF receptor-specific and c-Src-specific substrates
3.4 Receptor internalization
4. c-Src and the cytoskeleton
4.1 Focal adhesion kinase
4.2 p130CAS
4.3 p190RhoGAP
4.4 Cortactin (p80/85)
4.5 Sam68
5. Acknowledgments
6. References
7. Entire manuscript

Key words: c-Src tyrosine kinase; EGF/EGF receptor, Mitogenesis, Tumorigenesis, c-Src substrates, c-Src binding proteins, C3H10T murine fibroblasts

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