[Frontiers in Bioscience 2, d578-587, December 1, 1997]

	[Frontiers in Bioscience 2, d578-587, December 1, 1997] Reprints PubMed CAVEAT LECTOR
	HIV-1 NUCLEAR IMPORT: IN SEARCH OF A LEADER Michael I. Bukrinsky¹ and Omar K. Haffar² 1The Picower Institute for Medical Research, Manhasset, NY 11030, ²Cytokine Networks Inc., 101 Elliott Ave West, Suite 428, Seattle, WA 98119 Received 11/7/97 Accepted 11/14/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Cellular Nuclear Import Machinery 4. HIV-1 Nuclear Import 4.1. Role of active nuclear import in the HIV-1 life cycle 4.2. Viral proteins that regulate nuclear import 4.2.1. Matrix Antigen (MA) 4.2.2. Integrase (IN) 4.2.3. Viral Protein R (Vpr) 5. Nuclear Import as a Drug Target 5.1. Compounds which inactivate viral NLSs 5.2. Compounds which bind to karyopherin alpha 5.3. Perspectives for development of nuclear import inhibitors as anti-HIV drugs. 6. Summary and Conclusions 7. Acknowledgment 8. References 9. Entire manuscript Key words: Karyopherin, HIV-1, Vpr, Matrix antigen, Nuclear import, Anti-retroviral therapy, Preintegration complex Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d578-587, December 1, 1997]
Reprints
PubMed
CAVEAT LECTOR

HIV-1 NUCLEAR IMPORT: IN SEARCH OF A LEADER

Michael I. Bukrinsky¹ and Omar K. Haffar²

1The Picower Institute for Medical Research, Manhasset, NY 11030, ²Cytokine Networks Inc., 101 Elliott Ave West, Suite 428, Seattle, WA 98119

Received 11/7/97 Accepted 11/14/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Cellular Nuclear Import Machinery
4. HIV-1 Nuclear Import: 4.1. Role of active nuclear import in the HIV-1 life cycle
4.2. Viral proteins that regulate nuclear import
4.2.1. Matrix Antigen (MA)
4.2.2. Integrase (IN)
4.2.3. Viral Protein R (Vpr)
5. Nuclear Import as a Drug Target: 5.1. Compounds which inactivate viral NLSs
5.2. Compounds which bind to karyopherin alpha
5.3. Perspectives for development of nuclear import inhibitors as anti-HIV drugs.
6. Summary and Conclusions
7. Acknowledgment
8. References
9. Entire manuscript

Key words: Karyopherin, HIV-1, Vpr, Matrix antigen, Nuclear import, Anti-retroviral therapy, Preintegration complex

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.