[Frontiers in Bioscience 2, d460-470, September15, 1997]
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ACTION OF POLYPEPTIDE GROWTH FACTORS IN COLON CANCER; DEVELOPMENT OF NEW THERAPEUTIC APPROACHES

Subhas Chakrabarty, Sharon Reynolds, Hong mei Wang and Sriram Rajagopal

Division of Laboratory Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030

Received 9/3/97 Accepted 9/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. Adhesion molecules and TGF-beta
3.2. Mechanisms of action of TGF-beta in colon cancer, role of protein kinase C
3.3. PKC alpha-a potential therapeutic target
3.4. EGF family of growth factors and the potential of EGF receptor as a therapeutic target
3.5. Other potential therapeutic targets
3.6. Therapeutic approach
3.7. Basis of selectivity against colon cancer
3.8. Perspectives
4. Acknowledgments
5. References
8. Entire manuscript

Key words: TGF-beta, TGF-alpha, EGF, Growth factor receptors, Signal transduction, Cell adhesion, Therapeutics

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