[Frontiers in Bioscience 2, d460-470, September15, 1997]

	[Frontiers in Bioscience 2, d460-470, September15, 1997] Reprints PubMed CAVEAT LECTOR
	ACTION OF POLYPEPTIDE GROWTH FACTORS IN COLON CANCER; DEVELOPMENT OF NEW THERAPEUTIC APPROACHES Subhas Chakrabarty, Sharon Reynolds, Hong mei Wang and Sriram Rajagopal Division of Laboratory Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030 Received 9/3/97 Accepted 9/15/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Discussion 3.1. Adhesion molecules and TGF-beta 3.2. Mechanisms of action of TGF-beta in colon cancer, role of protein kinase C 3.3. PKC alpha-a potential therapeutic target 3.4. EGF family of growth factors and the potential of EGF receptor as a therapeutic target 3.5. Other potential therapeutic targets 3.6. Therapeutic approach 3.7. Basis of selectivity against colon cancer 3.8. Perspectives 4. Acknowledgments 5. References 8. Entire manuscript Key words: TGF-beta, TGF-alpha, EGF, Growth factor receptors, Signal transduction, Cell adhesion, Therapeutics Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d460-470, September15, 1997]
Reprints
PubMed
CAVEAT LECTOR

ACTION OF POLYPEPTIDE GROWTH FACTORS IN COLON CANCER; DEVELOPMENT OF NEW THERAPEUTIC APPROACHES

Subhas Chakrabarty, Sharon Reynolds, Hong mei Wang and Sriram Rajagopal

Division of Laboratory Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030

Received 9/3/97 Accepted 9/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion: 3.1. Adhesion molecules and TGF-beta; 3.2. Mechanisms of action of TGF-beta in colon cancer, role of protein kinase C; 3.3. PKC alpha-a potential therapeutic target; 3.4. EGF family of growth factors and the potential of EGF receptor as a therapeutic target; 3.5. Other potential therapeutic targets; 3.6. Therapeutic approach; 3.7. Basis of selectivity against colon cancer; 3.8. Perspectives
4. Acknowledgments
5. References
8. Entire manuscript

Key words: TGF-beta, TGF-alpha, EGF, Growth factor receptors, Signal transduction, Cell adhesion, Therapeutics

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.