Kuang Yu Chen

Department of Chemistry and The Cancer Institute of New Jersey, Rutgers - The State University of New Jersey, Piscataway, NJ. 08855-0939

Received 8/19/97 Accepted 8/25/97

7. REFERENCES

1. L. Hayflick & P. S. Moorhead: The serial cultivation of human diploid cell strains. Exp Cell Res 25, 585-621 (1961)

2. G.M. Martin, C.A. Sprague & C.J. Epstein: Replicative lifespan of cultivated human cells: Effect of donor's age, tissue and genotype. Lab Invest 23, 86-92 (1970)

3. V. J. Cristofalo & B. B. Sharf: Cellular senescence and DNA synthesis. Exp Cell Res 76, 419-427 (1973)

4. S. Goldstein: Replicative senescence: The human fibroblasts comes of age. Science 249, 1129-1133 (1990)

5. K.Y. Chen, Z.F. Chang, J.P. Pang, G.S. He & A.Y.-C. Liu: Polyamine metabolism and cell cycle-dependent gene expression in IMR-90 human diploid fibroblasts during senescence in culture. Exp Gerontol 24, 523-537 (1989)

6. Z-F. Chang & K. Y. Chen: Regulation of ornithine decarboxylase and other cell cycle-dependent genes during senescence of IMR-90 human diploid fibroblasts. J Biol Chem, 263, 11431-11435 (1988)

7. T. Seshadri & J. Campisi: Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247, 205-209 (1990)

8. G. H., Stein, L. F. Drulliner, R. S. Robetorye, O. M. Pereira-Smith & J. R. Smith: Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc Natl Acad Sci USA 88, 11012-11016 (1991)

9. J.P. Pang & K.Y. Chen: Global change of gene expression at late G1/S boundary may occur in human IMR-90 diploid fibroblasts during senescence. J Cell Physiol 160, 531-538 (1994)

10. J.P. Pang & K.Y. Chen: A specific CCAAT-binding protein, CBP/tk. may be involved in the regulation of thymidine kinase gene expression in human IMR-90 diploid fibroblasts during senescence. J Biol Chem 268, 2909-2916 (1993)

11. L.F. Good, G.P. Dimri, J. Campisi & K.Y. Chen: Regulation of dihydrofolate reductase gene expression and E2F components in human diploid fibroblasts during growth and senescence. J Cell Physiol 168, 580-588 (1996)

12. Z.F. Chang & C.J. Liu: Human thymidine kinase CCAAT-binding protein is NF-Y, whose A subunit expression is serum-dependent in human IMR-90 diploid fibroblasts. J Biol Chem 269, 17893-17898 (1994)

13, L.F. Good & K.Y. Chen: Cell cycle- and age-dependent transcriptional regulation of human thymidine kinase gene: The role of NF-Y in the CBP/tk binding complex. Biol Signals 5, 163-169 (1996)

14, S.N. Maity, S. Sinha, E.C. Ruteshouser & B. de Crombrugghe: Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor. J Biol Chem 267, 16574-16580 (1992)

15. I. Kovesdi, R. Reichel & J.R. Nevins: Identification of a cellular transcription factor involved in E1A trans-activation. Cell, 45, 219-228 (1986)

16. K. Helin, C.L. Wu, A. Fattaey, J.A. Lees, B.D. Dynlacht, C. Ngwu & E. Harlow: Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative transactivation. Genes & Dev 7, 1850-1861 (1993)

17. Y. Zhang & S. Challappan Cloning and characterization of human DP2, a novel dimerization partner of E2F. Oncogene 10, 2085-2093 (1995)

18. M. Meyyappan, P.W. Atadja & K.T. Riabowol: Regulation of gene expression and transcription factor binding activity during cellular aging. Biol Signals 5, 130-138 (1996)

19. Z.P. Chen & K.Y. Chen: Dramatic attenuation of hypusine formation on eukaryotic initiation factor 5A during senescence of IMR-90 human diploid fibroblasts. J Cell Physiol 170, 248-254 (1997).

20. G.P. Dimri & J. Campisi: Altered profile of transcription factor-binding activities in senescent human fibroblasts. Exp Cell Res 212, 132-140 (1994)

21. E. Neuman, E.K. Flemington, W.R. sellers & W.G. Kaelin, Jr: Transcription of the E2F-1 gene is rendered cell cycle-dependent by E2F DNA-binding sites within its promoter. Mol Cell Biol 14, 6607-6615 (1994)

22. J.H. Pang, Good, L.F. & K.Y. Chen: The age-dependent binding of CBP/tk, a CCAAT binding protein, is deregulated in transformed and immortalized mammalian cells but absent in premature aging cells. Exp Gerontol 31, 97-109 (1996)

23. L.F. Good, J. Chen & K.Y. Chen: Analysis of sequence-specific binding activity of cis-elements in human thymidine kinase gene promoter during G1/S phase transition. J Cell Physiol 163, 636-644 (1995)

24. D. Filatov & L. Thelander: Role of proximal NF-Y binding promoter element in S phase-specific expression of mouse ribonucleotide reductase R2 gene. J Biol Chem 270, 25239-25243 (1995)

25. A. Schulze, K. Zerfass, D. Spitkovsky, S. Middendorp, J. Berges, K. Helin, P. Jansen-Durr & B. Henglein: Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci USA 92, 11264-11268 (1995)

26. A. Kramer, C-P. Carstens & W.E. Fahl: A novel CCAAT-binding protein necessary for adhesion-dependent cyclin A transcription at the G1/S boundary is sequestered by a retinoblastoma-like protein in G0. J Biol Chem 271, 6579-6582 (1996)

27. A.P. Wolffe: Structural and functional properties of the evolutionarily ancient Y-box family of nucleic acid binding proteins. BioEssays 16, 245-251 (1994)

28. H. Chen, J. Campisi & R. Padmanabhan: SV40 large T antigen transactivates the human cdc2 promoter by inducing a CCAAT box binding factor. J Biol Chem 271, 13959-13967 (1996)