[Frontiers in Bioscience 2, d3417-426, September 1, 1997]
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TRANSCRIPTION FACTORS AND THE DOWN-REGULATION OF G1/S BOUNDARY GENES IN HUMAN DIPLOID FIBROBLASTS DURING SENESCENCE

Kuang Yu Chen

Department of Chemistry and The Cancer Institute of New Jersey, Rutgers - The State University of New Jersey, Piscataway, NJ. 08855-0939

Received 8/19/97 Accepted 8/25/97

TABLE OF CONTENTS

1. Abstract

2. Introduction
3. Changes of gene expression during senescence
3.1 Global attenuation of G1/S genes
3.2 Molecular basis for the global attenuation of G1/S genes
3.3 Binding activity as measured by gel mobility shift assay
3.4 The regulation of transcription factor activity during senescence
4. Transcriptional binding sites in the G1/S gene promoters
4.1 Promoter analysis of G1/S genes
4.2 Promoter organizations of TK and DHFR genes
4.3 Group 1 G1/S genes with CCAAT repeats within their promoters
4.4 Group 2 G1/S genes with E2F site within their promoters
4.5 Late G1/S genes containing other cis-elements within their promoters
4.6 Promoter analysis of NF-Y, NF-YB and E2F1
5. Perspective and summary
6.Acknowledgments
7. References
8. Entire manuscript
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