The DCC Protein -- NEURAL DEVELOPMENT AND THE MALIGNANT PROCESS

Kimberly M. Rieger-Christ, Karina L. Brierley and Michael A. Reale

Department of Internal Medicine/Oncology, Yale School of Medicine/West Haven Veterans Administration Medical Center, 333 Cedar St., P.O. Box 208032, New Haven, CT 06520-8032

Received 8/25/97 Accepted 9/5/97

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. DCC and Development

3.1. DCC guides axonal migrations

3.2 DCC guides cell migrations

3.3. Summary

4. DCC and Cancer

4.1. 18q Allelic loss and DCC expression studies

4.2. Experimental approaches

4.3. Summary

5. Perspective

6. Acknowledgments

7. References

6. ACKNOWLEDGMENTS

This work was supported by grants to M.A.R. from the National Institutes of Health (CA63297), the American Cancer Society (MGO-86203) and the Brain Tumor Society.