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The DCC Protein -- NEURAL DEVELOPMENT AND THE MALIGNANT PROCESS
Kimberly M. Rieger-Christ, Karina L. Brierley and Michael A. Reale
Department of Internal Medicine/Oncology, Yale School of Medicine/West Haven Veterans Administration Medical Center, 333 Cedar St., P.O. Box 208032, New Haven, CT 06520-8032
Received 8/25/97 Accepted 9/5/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. DCC and Development
- 3.1. DCC guides axonal migrations
- 3.2 DCC guides cell migrations
- 3.3. Summary
- 4. DCC and Cancer
- 4.1. 18q Allelic loss and DCC expression studies
- 4.2. Experimental approaches
- 4.3. Summary
- 5. Perspective
- 6. Acknowledgments
- 7. References
- 8. Entire manuscript
Key words:DCC (deleted in colorectal cancer), NCAM (neural cell adhesion molecule) , Netrins, Tumor suppressor, unc-40, Frazzled
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