Louise P. Cramer

The Randall Institute, Kings College London, 26-29 Drury Lane, London WC2B 5RL, UK.

Received 5/21/97; Accepted 5/26/97

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. Structural organization of actin filaments in lamellipodia

4. Types of actin-dependent motile force to drive retrograde particle flow relative to the substratum in lamellipodia

4.1 Actin flow-coupled mechanism

4.2 Alternative mechanisms to drive retrograde particle flow in lamellipodia

5. Function of retrograde actin flow in lamellipodia

6. Perspective

7. Acknowledgments

8. References

9. Entire manuscript

Keywords:cell locomotion, cell motility, fibroblast, neuron,keratocyte, myosin, actin, lamella,cell body, growth cone, centripetal flux, particle, protrusion