[Frontiers in Bioscience 2, d260-270, June 1, 1997]
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MOLECULAR MECHANISM OF ACTIN-DEPENDENT RETROGRADE FLOW IN LAMELLIPODIA OF MOTILE CELLS.

Louise P. Cramer

The Randall Institute, Kings College London, 26-29 Drury Lane, London WC2B 5RL, UK.

Received 5/21/97; Accepted 5/26/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Structural organization of actin filaments in lamellipodia
4. Types of actin-dependent motile force to drive retrograde particle flow relative to the substratum in lamellipodia
4.1 Actin flow-coupled mechanism
4.2 Alternative mechanisms to drive retrograde particle flow in lamellipodia
5. Function of retrograde actin flow in lamellipodia
6. Perspective
7. Acknowledgments
8. References
9. Entire manuscript

Keywords:cell locomotion, cell motility, fibroblast, neuron,keratocyte, myosin, actin, lamella,cell body, growth cone, centripetal flux, particle, protrusion

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