[Frontiers in Bioscience 2, d147-159, March 1, 1997]
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PATHOGENESIS AND TREATMENT OF HIV-1 INFECTION: RECENT DEVELOPMENTS

Stephen Dewhurst, Ph.D. and Linda Whetter, D.V.M., Ph.D.

Department of Microbiology and Immunology, and Cancer Center, University of Rochester Medical Center, Rochester NY

Received 2/21/97; Accepted 2/25/97; On-line 3/1/97

1. Abstract
2. Introduction
3. Discussion
3.1. Pathogenesis of HIV-1 infection
3.1.1. Viral replication and viral dynamics
3.1.2. Viral genetic variation
3.1.3. Protective host immune responses
3.1.4. Immunopathogenic mechanisms
4.1. Recent developments in anti-HIV-1 therapy
4.1.1. Protease inhibitors and combination therapy
4.1.2. Future directions
5. Perspective and Summary
6. References
7. Entire manuscript

Keywords : human immunodeficiency virus, acquired immunodeficiency syndrome, HIV, HIV-1, AIDS, lentivirus, antivirals, protease inhibitors, combination therapy, viral load, pathogenesis, chemokines, immune response